ACTRN12623000098639招募中3 期
The effectiveness of long-term treatment with azithromycin to prevent bronchiectasis and recurrent cough (LEAP-Cough) and developing individualised approaches for children with chronic wet cough
适应症
试验速览
- 阶段
- 3 期
- 状态
- 招募中
- 入组人数
- 274
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomised controlled trial
- 主要目的
- Prevention
- 盲法
- Blinded (masking used)
入排标准
- 年龄范围
- 2 Months 至 19 Years（—）
- 性别
- All
入选标准
- •1. Children aged 2 months-19 years
- •2. Suspected of having PBB i.e current or past history of chronic wet cough
- •3. Plan to remain in contact with one of the study sites for 24 months
- •4. Have one or more ‘high-risk traits’
- •Cough duration >6-months
- •Recurrent antibiotics use [>3 episodes to treat chronic wet cough in preceding 12-mo]
- •Airway Haemophilus influenzae infection.
排除标准
- •1.Presence of chronic cough pointers suggesting other causes of CWC- based on treating clinicians’ evaluation. (eg. bronchiectasis);
- •2. Known chronic lung disease eg. CT confirmed bronchiectasis (asthma not excluded as many children with PBB are misdiagnosed) or
- •3. Previously enrolled.
- •4. Contraindication to azithromycin (known liver dysfunction, known hypersensitivity to Azithromycin) or
- •5. Enrolled in another current RCT.
研究者
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