Acute effects of a physical high intensity workout on arterial stiffness and small airways

Not Applicable

• Conditions: ICD-10-CM: J45.990 Exercise-induced asthmaICD-10-CM: J00.J99 Diseases of the respiratory system: (Small-airways-disease); I20-I25; Ischaemic heart diseases

• Registration Number: DRKS00027508
• Lead Sponsor: niversitätsklinikum Schleswig Holstein, Medizinische Klinik III (Pulmologie)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2022-01-17
• Study Completion: 2022-10-31
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

1) Minimum age 18 years old
2) BMI-20-27,5kg/m²
3) No pre-existing diseases
4) Nonsmoker
5) High-performance athletes: sport, more than 10h exercise load per week
6) Control-group: less than 3h exercise per week and no prior exercise of high-performance sports
7) Written consent of the study-protocol
8) Exclusion of pregnancy, respectively hormonal contraception

Exclusion Criteria

1) Musculoskeletal diseases that make the execution of a spiroergometry impossible
2) Acute viral or bacterial infectious diseases
3) Any diseases that might pose a threat to the subject while being stressed physically
4) Severe dysrhythmia, heart deficiency
5) Pregnancy
6) Drug abuse
7) Participation in another drug study
8) Lack of compliance

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Primary endpoint is the expected increase of pulswave-velocity 15 minutes after the workout in both groups. <br><br>Hypothesis I:<br>After a workout up to their maximum physical ability subjects in both groups show an increased pulswave-velocity as a sign of blood-vessel-damage.<br><br>Null-hypothesis:<br>After a workout up to their maximum physical ability subjects in both groups do not show an increased pulswave-velocity.<br>Physical stress up to the individuals maximum physical ability does not lead to an increased pulswave-velocity as a sign of blood-vessel-damage, neither in high-performance athletes, nor in not-high-performance athletes.

Secondary Outcome Measures

Name	Time	Method
Secondary endpoints are the comparisons of both groups for parameters of peripheral and central haemodynamics, arterial stiffness and small airways in a resting situation prior to the spiroergometry and their alteration during the 30 minutes time period after the workout.<br>During this time period,Mobil-O-Graph-measurements will be taken in a 5 minute interval, small-airways-airwave-oscillometry through tremoFlo after 5, 10, 15 and 30 minutes.<br><br>Additionally the parameters of physical perfomance will be compared amongst each other.