Bioavailability of Lithium from mineral water
- Conditions
- Bioavailability in healthy subjects
- Registration Number
- DRKS00016063
- Lead Sponsor
- Institut für Humanernährung und Lebensmittelkunde, Chrisitan-Albrechts-Universität zu Kiel, Abteilung Humanernährung
- Brief Summary
Scope Lithium is an important trace element in human nutrition and medicine. Mineral and medicinal waters may represent a significant source of dietary lithium intake. Methods and results The lithium concentration of 360 German mineral and 21 medicinal waters is determined. Based on a systematic screening, three different mineral waters exhibiting low (1.7 µg L-1), medium (171 µg L-1), and high lithium (1724 µg L-1) concentrations are chosen for an acute bioavailability study in male healthy volunteers. In Germany, a north-east to south-west gradient of analyzed lithium concentrations is observed in the 381 tested waters. The lithium concentration in the water is significantly correlated with its sodium (r = 0. 810), potassium (r = 0.716), and magnesium (r = 0.361), but not with its calcium concentration. In a randomized cross-over trial, volunteers (n = 3×10 each) drink 1.5 L of the respective mineral waters, and lithium concentrations in serum and urine are monitored over 24 h. Consumption of the mineral waters with a medium and high lithium content results in a dose-dependent response in serum lithium concentrations and total urinary lithium excretion. Conclusion Lithium-rich mineral and medicinal waters may be an important and highly bioavailable lithium source for human consumption.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Male
- Target Recruitment
- 10
healthy subjects, BMI 20-29 kg/m^2
food allergies, alternative eating habits, smoking, chronic diseases, regular use of medications
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method ithium bioavailability as area under the serum lithium curve (iAUC)
- Secondary Outcome Measures
Name Time Method urinary lithium excretion and serum Brain Derived Neurotropic Factor levels over 24 hours