Towards individual medicine in ADHD: A pilot study on using individual differences in neural reward sensitivity to predict the efficacy of a behavioral intervention in ADHD (The SCORE! study).

Completed

Conditions: ADHD
Attention Deficit Hyperactivity Disorder
10009841

Registration Number: NL-OMON45061

Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 30

Inclusion Criteria

Inclusion criteria for patients (children with ADHD):
1. Age between 8;6 (8 years and 6 months) and 12;11 (12 years and 11 months).
2. A clinical diagnosis of ADHD (comorbidities are allowed in order to more closely reflect the typical clinical population), that is confirmed using the Disruptive Behavior Disorders Module (Module E) of the Diagnostic Interview Schedule for Children (DISC) (Schaffer, Fisher, Lucas, Dulcan, & Schwab-Stone, 2000).

Exclusion Criteria

1. Estimated IQ < 80, since cognitive behavioral treatments are generally not indicated in this IQ range.
2. A known (congenital) cardiovascular disease, since this may influence the ECG and subsequent analyses.
3. History of or present neurological disorder. A neurological disorder is defined as any disorder that requires care from a neurologist.

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>1. Change in the severity of ADHD symptoms as a result of treatment, measured<br /><br>with the well-validated Strengths and Weaknesses of ADHD and Normal behavior<br /><br>(SWAN) questionnaire (Lakes, Swanson, & Riggs, 2012).<br /><br>2. Physiological response to reward as measured by changes in heart rate<br /><br>variability or skin conductance change during both reward tasks.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>1. Reward sensitivity as measured by (a) the total reward sensitivity score on<br /><br>the SPSRQ-C, the Sensitivity to Punishment and Sensitivity to Reward<br /><br>Questionnaire for children; (b) Reward sensitivity index (response time<br /><br>distribution shift under rewarded versus non-rewarded conditions) from the<br /><br>child-friendly version of the Monetary Incentive Delay task and percentage of<br /><br>advantageous doors chosen from the Hungry Donkey Task (a child-friendly version<br /><br>of the Iowa Gambling Task).<br /><br>2. Parental ratings of current stress related to parenting their child, as<br /><br>measured by the Nijmeegse Ouder Stress Index (NOSI), which is a translation of<br /><br>the well-validated Parenting Stress Index. </p><br>