IRCT20161010030246N6尚未招募3 期
Evaluating the effectiveness of silymarin in preventing vancomycin-induced nephrotoxicity in hospitalized patients
适应症
试验速览
- 阶段
- 3 期
- 状态
- 尚未招募
- 入组人数
- 80
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 years 至 no limit（—）
- 性别
- All
入选标准
- •Hemodynamic stability (mean arterial blood pressure above 70 mmHg and/or systolic blood pressure above 90 mmHg.
- •Willingness to participate in the study
- •Receiving vancomycin intravenously for at least 1 week with the maintenance dosage regimen of 30-45 mg/kg/day or 1-2 g twice a day. Notably, the vancomycin regimen is the same in both hospitals.
排除标准
- •Confirmed history of acute kidney injury
- •Confirmed history of chronic kidney disease
- •Taking vancomycin within the last 14 days
- •Taking silymarin orally at least during the past day
- •Confirmed history of hypersensitivity reactions following oral consumption of silymarin
- •Simultaneous use of agents with antioxidant activity such as vitamin C, vitamin E, vitamin A, melatonin
- •Receiving drugs with high nephrotoxicity potential such as aminoglycosides, amphotericin b, colistin
- •Oral intolerance to drugs
研究者
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