Exercise in Pregnant Women With Gestational Diabetes
- Conditions
- Gestational Diabetes
- Interventions
- Behavioral: physical activity
- Registration Number
- NCT04145479
- Lead Sponsor
- Oregon Health and Science University
- Brief Summary
Gestational diabetes (GDM) impacts 1 in 10 pregnancies; hyperglycemia and hypertriglyceridemia are common features of the condition. Women are recommended to do at least 150 minutes of moderate-intensity aerobic activity a week during pregnancy and the postpartum period. Exercise both during and out of pregnancy has been shown to be an effective non-pharmacologic tool to reduce glucose and lipid profiles. The goals and purpose of this pilot study is to 1) determine the influence of exercise and the timing of exercise surrounding a meal on glucose and lipid metabolism in pregnant women with GDM and 2) determine the feasibility of low-resistance and aerobic activity and measuring exercise metrics during pregnancy. The overarching objective of this study is to determine the effects of low-resistance and aerobic exercise on glucose and lipids following a meal in pregnant women with GDM.
- Detailed Description
Gestational diabetes (GDM) impacts 1 in 10 pregnancies; hyperglycemia and hypertriglyceridemia are common features of the condition. Women are recommended to do at least 150 minutes of moderate-intensity aerobic activity a week during pregnancy and the postpartum period. Exercise both during and out of pregnancy has been shown to be an effective non-pharmacologic tool to reduce glucose and lipid profiles. The goals and purpose of this pilot study is to 1) determine the influence of exercise and the timing of exercise surrounding a meal on glucose and lipid metabolism in pregnant women with GDM and 2) determine the feasibility of low-resistance and aerobic activity and measuring exercise metrics during pregnancy. The overarching objective of this study is to determine the effects of low-resistance and aerobic exercise on glucose and lipids following a meal in pregnant women with GDM. Women will perform either low-resistance or aerobic exercise. Blood will be taken before and 2 hours after a fixed meal. For safety, women will have supervised exercise and oxygen consumption will be measured throughout the activity.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- Female
- Target Recruitment
- 12
- diet and lifestyle controlled gestational diabetes
- Gestational age 28 weeks-32 weeks gestation
- Age 18-50 years
- Singleton pregnancy
- Chronic hypertension
- Pregestational diabetes
- History of peripartum cardiomyopathy
- Any condition contraindicating for exercise
- Taking any cardiovascular modifying medications (beta-blockers, calcium channel blockers, corticosteroids)
- Asthma or other underlying lung disease that is equivalent or worse than persistent mild classification (defined as at least >2 day/week asthmatic symptoms, 1-2x/month nighttime awakenings, >2days/week short-acting beta-agonist use for symptom control, and minor limitations with normal activity; ≥2 exacerbations in 6 months requiring oral systemic corticosteroids, ≥4 wheezing episodes/1 year lasting >1 day)
- Congenital anomalies
- Multifetal gestation
- Current alcohol use
- Current tobacco use
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description low-resistance physical activity women will perform low-resistance physical activity aerobic physical activity women will perform aerobic physical activity
- Primary Outcome Measures
Name Time Method postprandial glucose 2 hours after meal glucose measure after meal following exercise compared to no exercise
postprandial triglyceride 2 hours after meal triglyceride measure after meal following exercise compared to no exercise
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Oregon Health and Science University
🇺🇸Portland, Oregon, United States