Evaluating the Effects of Low-resistance and Aerobic Exercise on Glucose and Lipids in Pregnant Women With Gestational Diabetes
Trial Snapshot
- Phase
- Not Applicable
- Enrollment
- 12
- Locations
- 1
- Primary Endpoint
- postprandial glucose
Study Overview
Brief Summary
Gestational diabetes (GDM) impacts 1 in 10 pregnancies; hyperglycemia and hypertriglyceridemia are common features of the condition. Women are recommended to do at least 150 minutes of moderate-intensity aerobic activity a week during pregnancy and the postpartum period. Exercise both during and out of pregnancy has been shown to be an effective non-pharmacologic tool to reduce glucose and lipid profiles. The goals and purpose of this pilot study is to 1) determine the influence of exercise and the timing of exercise surrounding a meal on glucose and lipid metabolism in pregnant women with GDM and 2) determine the feasibility of low-resistance and aerobic activity and measuring exercise metrics during pregnancy. The overarching objective of this study is to determine the effects of low-resistance and aerobic exercise on glucose and lipids following a meal in pregnant women with GDM.
Detailed Description
Gestational diabetes (GDM) impacts 1 in 10 pregnancies; hyperglycemia and hypertriglyceridemia are common features of the condition. Women are recommended to do at least 150 minutes of moderate-intensity aerobic activity a week during pregnancy and the postpartum period. Exercise both during and out of pregnancy has been shown to be an effective non-pharmacologic tool to reduce glucose and lipid profiles. The goals and purpose of this pilot study is to 1) determine the influence of exercise and the timing of exercise surrounding a meal on glucose and lipid metabolism in pregnant women with GDM and 2) determine the feasibility of low-resistance and aerobic activity and measuring exercise metrics during pregnancy. The overarching objective of this study is to determine the effects of low-resistance and aerobic exercise on glucose and lipids following a meal in pregnant women with GDM. Women will perform either low-resistance or aerobic exercise. Blood will be taken before and 2 hours after a fixed meal. For safety, women will have supervised exercise and oxygen consumption will be measured throughout the activity.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Single Group
- Primary Purpose
- Supportive Care
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 50 Years (Adult)
- Sex
- Female
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •diet and lifestyle controlled gestational diabetes
- •Gestational age 28 weeks-32 weeks gestation
- •Age 18-50 years
- •Singleton pregnancy
Exclusion Criteria
- •Chronic hypertension
- •Pregestational diabetes
- •History of peripartum cardiomyopathy
- •Any condition contraindicating for exercise
- •Taking any cardiovascular modifying medications (beta-blockers, calcium channel blockers, corticosteroids)
- •Asthma or other underlying lung disease that is equivalent or worse than persistent mild classification (defined as at least >2 day/week asthmatic symptoms, 1-2x/month nighttime awakenings, >2days/week short-acting beta-agonist use for symptom control, and minor limitations with normal activity; ≥2 exacerbations in 6 months requiring oral systemic corticosteroids, ≥4 wheezing episodes/1 year lasting >1 day)
- •Congenital anomalies
- •Multifetal gestation
- •Current alcohol use
- •Current tobacco use
Arms & Interventions
low-resistance
women will perform low-resistance physical activity
Intervention: physical activity (Behavioral)
aerobic
women will perform aerobic physical activity
Intervention: physical activity (Behavioral)
Outcomes
Primary Outcomes
postprandial glucose
Time Frame: 2 hours after meal
glucose measure after meal following exercise compared to no exercise
postprandial triglyceride
Time Frame: 2 hours after meal
triglyceride measure after meal following exercise compared to no exercise
Secondary Outcomes
No secondary outcomes reported
Investigators
Amy Miyoshi Valent
Assistant Professor
Oregon Health and Science University