Betacel dysfunction induced by impaired pancreas anatomy and insulin sensitivity in subjects with heterozygous EXT1 or EXT2 Mutations

Completed

• Conditions: diabetes; 10018424

• Registration Number: NL-OMON38131
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 40

Inclusion Criteria

Caucasian subjects (male/female), aged between 18-65 years of age with heterozygous EXT-1 or EXT-2 mutations as well as unaffected related controls matched for age and gender and subjects wiht known type 2 diabetes mellitus.

Exclusion Criteria

claustrophobia, pregnant subjects or female participant at childbearing age not using adequate anticonception, renal dysfunction during screening, exogenous insulin use.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>-pancreas size (MRI)</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- pancreas permeability (MRI) </p><br>