Effects of Chronic Dietary Grape Seed Extract Supplementation on Aortic Stiffness and Hemodynamic Responses to Exercise in Obese Males
- Conditions
- Obesity Adult Onset
- Interventions
- Dietary Supplement: Grape Seed Extract
- Registration Number
- NCT04465110
- Lead Sponsor
- California Baptist University
- Brief Summary
It was demonstrated that acute dietary supplementation with GSE reduced arterial blood pressure via reduction in Q in obese individuals. However, no studies have investigated the chronic effects of dietary GSE supplementation on hemodynamic responses during exercise. Given the fact that obesity is associated with an impaired function of eNOS, the effect of chronic dietary GSE supplementation on abnormal blood pressure response to exercise and aortic stiffness (AoS) needs be elucidated. Thus, it is hypothesized that GSE decreases systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), Q, and aortic stiffness at rest and during exercise. This study would determine that this supplementation may be used as a non-pharmacological intervention to prevent incident hypertension and cardiovascular events during exercise via enhanced endothelial function.
- Detailed Description
We investigated whether elevated blood pressure and aortic stiffness (AoS) characterized in obese and overweight males (N=10) are reduced following chronic GSE supplementation during exercise. Systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), heart rate (HR), stroke volume (SV), cardiac output (Q), total vascular conductance (TVC), and AoS to two submaximal cycling exercises (40% and 60% VO2peak) were compared 7 days after ingestion of GSE or placebo (PL) within an one week washout period. Compared with PL, GSE supplementation significantly decreased MAP at rest, 40%, and 60% workloads. AoS was significantly reduced at rest. Q tended to be decreased, but there was no significant difference. GSE had no effect on HR, TVC, and SV. Our study indicates that chronic supplementation with GSE reduces arterial pressure at rest and during exercise primarily via the combined reduction of AoS and Q. Thus, GSE can be a dietary supplement to treat augmented blood pressure responses in obese and overweight males at rest and during exercise.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 10
- Overweight: 25-29.9 kg/m2
- Obese: > 30 kg/m2
- Waist circumference: > 90 cm
- Antihypertensive medication
- Major systemic disease (cancer)
- Musculoskeletal diseases
- Cardiovascular diseases or symptoms including chest pain
- Myocardial infarction
- Arrhythmias
- Heart failure
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description GSE group Grape Seed Extract Subjects took a single dose of 600 mg GSE in capsule form through ingestion 7 days Placebo group Grape Seed Extract Subjects took a single dose of 600 mg starch in capsule form through ingestion 7 days
- Primary Outcome Measures
Name Time Method change in heart rate at rest and during exercise 7 day supplementation beats per minute
change in stroke volume at rest and during exercise 7 day supplementation volume per stroke
change in systolic blood pressure at rest and during exercise 7 day supplementation pressure exerted during contraction
change in cardiac output at rest and during exercise 7 day supplementation total volume for one minute
change in aortic stiffness at rest 7 day supplementation Arbitrary unit
change in total vascular conductance at rest and during exercise 7 day supplementation one reported value (cardiac output/mean arterial pressure)
change in diastolic blood pressure at rest and during exercise 7 day supplementation pressure exerted during relaxation
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
California Baptist University
🇺🇸Riverside, California, United States