Cardiovascular Reactivity to Physical Stress: Strategies and Mechanisms
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 45
- 试验地点
- 1
- 主要终点
- Blood pressure (unit: mmHg) response to laboratory stressors
研究概览
简要总结
It is well-accepted that an exaggerated blood pressure (BP) response to physical stress has a prognostic value, indicating a higher cardiovascular risk (e.g., sudden cardiac death, myocardial infarction, future hypertension, and left ventricular hypertrophy). However, there is a limited understanding of the underlying mechanisms and therapuetic strategies modulating this response. Therefore, this pilot project aims to explore whether one session of low-volume high-intensity interval training (low-volume HIIT) or combined intermittent heat and cold bath (sauna+cold bath) can decrease BP responses to physical stress. Furthermore, the secondary goal is to investigate whether one brief session learning about positive stress expectations magnifies the decrease in BP following low-volume HIIT and sauna+ cold bath.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Male or female between 18 to 50 years
- •Non-smoker.
- •Non-obese (<30 kg/m2).
- •Able to walk on a treadmill and cycle on a stationary bike without problems.
- •No or little (frequency < 2 times per month) experience swimming with sauna and cold water.
- •Proficient in Norwegian and able to provide informed consent.
排除标准
- •Current or previous regular smoker
- •Addictions to alcohol or illegal drugs
- •Diagnosed with cardiovascular, respiratory, metabolic, or autoimmune diseases
- •Taking prescription medication with known cardiovascular effects
- •Judgment by a medical provider that exercise, heat therapy, or hydrotherapy poses an undue burden or risk.
- •Cognitive or psychiatric impairment
- •Lack of proficiency in Norwegian language oral or writing skills that will hamper the ability to participate in the interventions and fill out questionnaires.
研究组 & 干预措施
Positive stress education (PSE)
This intervention will consist of standardized information about the relationships between expectations and the stress response. Using the CATS as a theoretical framework, the participants will be explained that when people face stressors, i.e., pain, heat, and cold water, the expectations about handling the situation will influence both the experience (e.g., pain) and the physiological stress response.
干预措施: Low-volume high intensity exercise (Other)
Positive stress education (PSE)
This intervention will consist of standardized information about the relationships between expectations and the stress response. Using the CATS as a theoretical framework, the participants will be explained that when people face stressors, i.e., pain, heat, and cold water, the expectations about handling the situation will influence both the experience (e.g., pain) and the physiological stress response.
干预措施: Combined intermittent sauna and cold water bath (sauna+cold bath). (Other)
Neutral control
To control for the PSE intervention, the participants will receive 15 min of neutral information about the effects of physical exercise on cardiovascular fitness.
干预措施: Low-volume high intensity exercise (Other)
Neutral control
To control for the PSE intervention, the participants will receive 15 min of neutral information about the effects of physical exercise on cardiovascular fitness.
干预措施: Combined intermittent sauna and cold water bath (sauna+cold bath). (Other)
结局指标
主要结局
Blood pressure (unit: mmHg) response to laboratory stressors
时间窗: Assessment will be completed before intervention and approximately 30 minutes after intervention
Response will be calculated as the change from baseline to peak. Stressors employed include handgrip exercise, post-exercise ischemia, and cold pressor test.
次要结局
- Resting blood pressure (mmHg).(Assessment will be completed before intervention and approximately 30 minutes after intervention)
- Subjective ratings of expectancies (point score).(Assessment will be completed before intervention and approximately 30 minutes after intervention.)
- Endothelial function (% dilation)(Assessment will be completed before intervention and approximately 30 minutes after intervention.)
研究者
Ann-Katrin Grotle
Associate professor
Western Norway University of Applied Sciences