Courbes Normatives De Volumes Cérébraux Issues D'IRM Fœtales Multicentriques
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Cortical Development Malformation
- Sponsor
- Assistance Publique Hopitaux De Marseille
- Enrollment
- 1423
- Locations
- 1
- Primary Endpoint
- Determine normative brain volume curves
- Status
- Recruiting
- Last Updated
- 10 months ago
Overview
Brief Summary
Fetal brain MRI is an essential diagnostic tool to inform parents about the prognosis of abnormalities detected on routine ultrasound. Recent work has shown that brain MRI measurements at the antenatal stage are predictive of the child's postnatal development. However, this work remains limited to basic research, in part because of the lack of normative curves of brain tissue volume evolution from fetal MRI acquired in clinical routine. This project aims to fill this gap. For this purpose, the project will exploit fetal MRI scans acquired in 4 French hospitals (Marseille, Nice, Montpellier and Paris): MRI scans without abnormalities will be centralized for analysis, and families who have undergone these scans will be contacted to evaluate the development of their children after birth. Normative curves will be established by applying a set of treatments developed by the laboratory in Marseille collaborating in the project. Ultimately, these curves will help to clarify the diagnosis of fetuses by providing a quantitative characterization of the normality of brain measurements.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Child who has had, more than 3 years ago, a cerebral MRI during the fetal period in one of the 4 partner centers
Exclusion Criteria
- •Child suffering from a commissural malformation (anomaly of the corpus callosum)
- •Child with a genetic syndrome and/or chromosomal abnormality and/or deleterious mutation
- •Child with syndromic extra-cerebral malformations (including cardiac malformations)
- •Child with intrauterine growth restriction reported in the obstetrical record
- •Child with maternal-fetal infection (TORCH, parvovirus or other) confirmed by amniotic fluid test or neonatal urine test
- •Multiple pregnancy
- •Mother with diabetes treated during pregnancy (including gestational diabetes, if treated)
- •Mother with antiepileptic medication during pregnancy
- •Alcohol or drug use
- •Presence of a sustentorial arachnoid cyst
Outcomes
Primary Outcomes
Determine normative brain volume curves
Time Frame: Through study completion, an average of 3 year
Curves calculated from fetal brain MRIs in fetuses between 20 and 37 weeks of amenorrhea with normal postnatal neurological development
Secondary Outcomes
- Statistically compare the normative curves obtained with standard articles in the literature.(Through study completion, an average of 3 year)
- Sensitivity study: Possible influence of the scanner type on the estimated normative curves.(Through study completion, an average of 3 year)