Fear-Potentiated Startle Method Adaptation Studies: Processing of repeatedly presented stimuli

Completed

• Conditions: induced anxiety in healthy volunteers; 10002861

• Registration Number: NL-OMON30886
• Lead Sponsor: niversiteit Utrecht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 13 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 40

Inclusion Criteria

- Subject is a legally competent adult, aged 18 to 40.
- Subject is familiar with the procedures of the study, and agrees to participate in the study program by giving written informed consent.

Exclusion Criteria

- Subject is mentally or legally incapacitated, has significant emotional problems at the time of the study, or has a history of any significant psychiatric disorder(s). Subjects with extreme psychological responses in the personality questionnaires can be excluded.
- Subject has a history of any cardiac disorder or neurological disease.
- Subject has participated in another FPS trial prior to the start of the study.
- Subject is currently a regular user (including *recreational uses*) of any illicit drugs, or has (a history of) drug or alcohol abuse.
- Subject is unable to discern basic colours red, green and blue.
- Reduced startle reactivity, defined as no discernable response in at least 3 out of the 12 startle stimuli.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study parameter is potentiation of the startle reflex during a<br /><br>condition in which electrical stimuli may be administered in comparison to<br /><br>startle during a safe condition in which electrical stimuli will never be<br /><br>presented (FPS). </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Skin conductance responses, subjective anxiety.</p><br>