JPRN-UMIN000004826CompletedPhase 2
Randomized crossover trial of Granisetron/Dexamethasone/Aprepitant versus Palonosetron/Dexamethasone/Aprepitant for the prevention of nausea and vomiting in patients receiving receiving Cisplatin containing chemotherapy for head and neck cancer - Randomized crossover trial of Granisetron/Dexamethasone/Aprepitant versus Palonosetron/Dexamethasone/Aprepitant for the prevention of nausea and vomiting in patients receiving receiving Cisplatin containing chemotherapy for head and neck cancer
Yokohama City University Graduate School of Medicine0 sites60 target enrollmentStarted: January 6, 2011Last updated:
Conditions
Trial Snapshot
- Phase
- Phase 2
- Status
- Completed
- Sponsor
- Enrollment
- 60
Study Overview
Brief Summary
No summary available.
Study Design
- Study Type
- Interventional
Eligibility Criteria
- Ages
- 20years-old to 75years-old (—)
- Sex
- All
Inclusion Criteria
- Not provided
Exclusion Criteria
- •1) with seizure disorder needing anticonvulsants unless clinically stable 2) with vomiting, retching, or grade 2 or higher nausea according to CTCAE 3) with QTc prolongation by electrocardiography (QTc: >470 msec) 4) with severe allergy to Palonosetron, Granisetron, Aprepitant and Dexamethasone 5) pregnant or nursing women or women who like be pregnant and men with partner willing to get pregnant 6) receiving an antiemetic drug 7) receiving pimozide (orap) 8) with history of mental disorder or treating it at the moment 9) doctor's decision not to be registered to this study
Investigators
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