The Effect of 6 Month High Intensity Progressive Resistance Training on Knee Articular Cartilage Morphology in Female Osteoarthritic Patients
Trial Snapshot
- Phase
- Phase 2
- Sponsor
- University of Sydney
- Enrollment
- 60
- Locations
- 2
- Primary Endpoint
- Articular cartilage morphology following 6 months high intensity progressive resistance training
Study Overview
Brief Summary
Female subjects over the age of 40 will be recruited and randomised into a progressive resistance training (PRT) or sham-exercise group. The PRT group will train at 80% of their peak strength, using Keiser pneumatic resistance machines, and progress approximately 3% per session. Strength will be re-assessed fortnightly. Exercises will target muscles around the hip and knee. The sham-exercise group will train on the same equipment as the PRT group except hip adduction, but without added resistance or progression. Both groups will train 3 days per week for roughly 45 minutes for 6 months.
It is hypothesised that high intensity PRT will decelerate the tibial and femoral cartilage degeneration in the knee affected most by OA.
Primary Outcome:
Articular cartilage morphology following 6 months high intensity progressive resistance training
Secondary Outcomes:
Muscle and fat cross-sectional area (CSA) (pre and post) Muscle strength, power, endurance, and contraction velocity (pre, 3 months, & post) Medications (pre, 3 months, & post) Body composition (pre, 3 months, & post) Balance; Physical function (pre, 3 months, & post) Questionnaires (pre, 3 months, & post)
- Habitual exercise (PASE) -WOMAC index (pain, stiffness and functional ability)
- Depressive symptoms (Depression Scale) -Quality of life (SF36)
- Confidence performing physical activity (Ewart) -Demographics
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- Single
Eligibility Criteria
- Ages
- 40 Years to — (Adult, Older Adult)
- Sex
- Female
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Aged over 40 years old
- •Primary Osteoarthritis in at least one knee using standard criteria of the American College of Rheumatology (ACR) criteria for classification of clinical osteoarthritis
- •Ambulatory without human assistance
- •Willingness to be randomised to experiential or control group
- •Ability to attend scheduled exercise and testing sessions
Exclusion Criteria
- •Regular exercise of any kind over the past 3 months (>1dpw).
- •Secondary osteoarthritis (traumatic or post-surgical), rheumatic disease, gouty or septic arthritis, Paget's disease, pseudogout, major congenital abnormalities, hemochromatosis, Wilson's disease and other rare forms of arthritis
- •Joint injury, injection or surgery within the past 6 months or knee joint replacement
- •Contraindications to MRI/Exercise
Outcomes
Primary Outcomes
Articular cartilage morphology following 6 months high intensity progressive resistance training
Secondary Outcomes
- Muscle strength, power, endurance, and contraction velocity (pre, 3 months, & post)
- Muscle and fat cross-sectional area (CSA) (pre and post)
- Medications (pre, 3 months, & post)
- Body composition (pre, 3 months, & post)
- Balance; Physical function (pre, 3 months, & post)
- Questionnaires (pre, 3 months, & post):
- Habitual exercise (PASE)
- WOMAC index (pain, stiffness and functional ability)
- Depressive symptoms (Depression Scale)
- Quality of life (SF36)
- Confidence performing physical activity (Ewart)
- Demographics