The Role of Ambulatory Blood Pressure Characteristics, Features of the Structural and Functional Vascular Wall State, the Presence and Severity of Obstructive Sleep Apnea Syndrome in Predicting the "Escape" Phenomenon of the Antihypertensive Therapy Efficacy.
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Arterial Hypertension
- Sponsor
- Federal State Budgetary Institution NATIONAL MEDICAL RESEARCH CENTRE OF CARDIOLOGY NAMED AFTER ACADE
- Enrollment
- 165
- Locations
- 1
- Primary Endpoint
- Assessment of BP increasing higher the target level when taking the same therapy
- Status
- Active, not recruiting
- Last Updated
- 3 years ago
Overview
Brief Summary
A little attention is paid to the AHT efficacy escaping problem, which can be explained by the AHT correction simplicity and rapid achievement of the target BP level. Nevertheless, modern statistic data on the effective AH treatment described above let us assume that AHT correction is either totally absent or is untimely in case of the "escape" phenomenon development. This could be one of the main reasons for the high prevalence of ineffective AH treatment. The aim of this study is to determine AHT efficacy "escape" phenomenon timeline and its predictors in hypertensive patients.
Investigators
Mikhailova Oksana
Dr., clinical reseacher
National Medical Research Center for Cardiology, Ministry of Health of Russian Federation
Eligibility Criteria
Inclusion Criteria
- •Arterial hypertension (AH) grade 1-3, stage I-II
- •High compliance during the follow-up period (≥ 85%)
- •Initially achieved target office BP levels while taking 2-3-component AHT
Exclusion Criteria
- •Secondary AH
- •Resistant AH,
- •AH III stage,
- •PAP- therapy,
- •type 2 diabetes mellitus,
- •pregnancy
- •history of low adherence to treatment
Outcomes
Primary Outcomes
Assessment of BP increasing higher the target level when taking the same therapy
Time Frame: 1-6 months
Assessment of attenuation of efficacy of previously adequate antihypertensive therapy by using different BP measurement methods
Secondary Outcomes
- Disease course: assessment of major CVE and death occurrence(10 years)