The Role of Ambulatory Blood Pressure Characteristics, Features of the Structural and Functional Vascular Wall State, the Presence and Severity of Obstructive Sleep Apnea Syndrome in Predicting the "Escape" Phenomenon of the Antihypertensive Therapy Efficacy.
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 165
- 试验地点
- 1
- 主要终点
- Assessment of BP increasing higher the target level when taking the same therapy
研究概览
简要总结
A little attention is paid to the AHT efficacy escaping problem, which can be explained by the AHT correction simplicity and rapid achievement of the target BP level. Nevertheless, modern statistic data on the effective AH treatment described above let us assume that AHT correction is either totally absent or is untimely in case of the "escape" phenomenon development. This could be one of the main reasons for the high prevalence of ineffective AH treatment. The aim of this study is to determine AHT efficacy "escape" phenomenon timeline and its predictors in hypertensive patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Arterial hypertension (AH) grade 1-3, stage I-II
- •High compliance during the follow-up period (≥ 85%)
- •Initially achieved target office BP levels while taking 2-3-component AHT
排除标准
- •Secondary AH
- •Resistant AH,
- •AH III stage,
- •PAP- therapy,
- •type 2 diabetes mellitus,
- •pregnancy
- •history of low adherence to treatment
结局指标
主要结局
Assessment of BP increasing higher the target level when taking the same therapy
时间窗: 1-6 months
Assessment of attenuation of efficacy of previously adequate antihypertensive therapy by using different BP measurement methods
次要结局
- Disease course: assessment of major CVE and death occurrence(10 years)
研究者
Mikhailova Oksana
Dr., clinical reseacher
National Medical Research Center for Cardiology, Ministry of Health of Russian Federation