TCTR20181010001已完成2 期
The effects of Limited Infusion rate of Fluid in the Early resuscitation of Sepsis on Syndecan-1 Shedding: a randomized controlled trial
Jutamas Saoraya0 个研究点目标入组 98 人开始时间: 2018年10月10日最近更新:
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 发起方
- 入组人数
- 98
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 Years 至 0 N/A (No limit)（—）
- 性别
- All
入选标准
- •1.adults aged 18 or over
- •2.with suspected sepsis according to the sepsis-3 definition identified by [18]
- •a.suspected infection with
- •b.qSOFA ≥ 2/3
- •i.alteration in mental status
- •ii.Systolic Blood Pressure (SBP) ≤ 100 mmHg
- •iii.Respiratory rate (RR) ≥ 22/min
- •3.and hypoperfusion as by clinician’s decision to use fluid bolus therapy for 30 ml/kg including
- •a.Systolic Blood Pressure (SBP) < 90 mmHg,
- •b.MAP < 65 mmHg
- •c.lactate ≥ 2 mmol/L.
排除标准
- •1.Received resuscitation fluid for more than 500 ml.
- •2.Severe hypotension (SBP < 70 mmHg)
- •3.Suspected other main causes of hypoperfusion (obstructive, cardiogenic, hypovolemic such as gastrointestinal hemorrhage)
- •4.Concurrent acute heart failure or known left ventricular ejection fraction (LVEF) less than 40% or poor LVEF by eyeballing on point of care ultrasound (POCUS)
- •5.End stage renal disease (ESRD) with chronic RRT
- •6.Suspected infection from microorganisms other than bacteria
- •7.Potentially need for immediate surgery in 6 hours
- •8.Body mass index (BMI) ≥ 30 kg/m2
- •9.Concurrent acute traumatic brain injury
- •10.Do-Not-Attempt-Resuscitation (DNAR) order status
- •11.Transferred from another hospital
- •12.Pregnancy
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