Pattern of Intestinal Parasitic Infection Among Cirrhotic Patients in Sohag University Hospital

Not Applicable

Not yet recruiting

• Conditions: Liver Cirrhosis
• Interventions: Diagnostic Test: stool analysis

• Registration Number: NCT05856721
• Lead Sponsor: Sohag University

Brief Summary

Chronic hepatic illness is one of the most serious health issues . Liver cirrhosis as the latest phase of chronic liver disease causes a disorder called cirrhosis-associated immune dysfunction syndrome (CAIDS) . Cirrhosis comes to be a systemic disease, with several organ disorders. At this phase, patients become highly vulnerable to various infections because of CAIDS, which comprises both innate and adaptive immunity). Patients with hepatic cirrhosis and ascites are more liable to other complications of liver disease, including hyponatremia, refractory ascites, or hepatorenal syndrome (HRS) . Liver cirrhotic patients are considered to be as immunosuppressed and are vulnerable to a different species of entero-parasites .

Intestinal parasitic diseases have been reported in association with diabetes mellitus (DM) which is considered a predisposing factor to infection in cirrhotic patients . Immunosuppression among DM cases is due to increased blood glucose levels, which modifies several immune responses and this renders the body susceptible to various opportunistic infections comprising parasitic infections

Intestinal parasites such as Blastocystis hominis, Cryptosporidium spp., Isospora belli, Cyclospora cayetanensis, and Microsporidia have appeared as significant opportunistic parasites that are responsible for severe illness in immunocompromised patients , subsequently, patients suffer from severe morbidity and high mortality).

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Status Verified: 2023-05
• Study First Submitted: 2023-05-03
• Study First Submitted QC: 2023-05-03
• Last Update Submitted: 2023-05-03
• Study First Posted: 2023-05-12
• Last Update Posted: 2023-05-12
• Study Start: 2023-06
• Primary Completion: 2024-06
• Study Completion: 2024-06

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

• Patients diagnosed to have liver cirrhosis with or without hepatocellular carcinoma.

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Exclusion Criteria

• . Cirrhotic patients with renal impairment.
• . Cirrhotic patients with cardiac diseases.

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
control group	stool analysis	One hundred patients with GIT complaints but not have any cormobidity
cases group	stool analysis	One hundred patients with liver cirrhosis and GIT complaints

Primary Outcome Measures

Name	Time	Method
Pattern of Intestinal Parasitic Infection Among Cirrhotic Patients	12 months	Detection of prevalence and pattern of intestinal parasitic infection in cirrhotic patients and the difference between cirrhotic patients and non-cirrhotic patients with no comorbidity.; To determine the most common risk factors of intestinal parasitic infection in cirrhotic patients

Trial Locations

Locations (1)

Sohag university hospital; 🇪🇬 Sohag, Egypt