Amyloidosis Typing Using Mass Spectrometry-based Proteomics: a New Accurate Tool for Difficult Typing
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 27
- 试验地点
- 1
- 主要终点
- Amyloidosis typing
研究概览
简要总结
The main objective is to establish that a new technique of amyloidosis typing by Proteomics (based on nanoLC-MS/MS mass spectrometry) allows typing in > 90% of observations in patients whose Amyloidosis is reported to have failed typing (impossible typing, uncertain or inconsistent) with the traditional anatomopathological approach, and this in a cohort of 40 patients identified consecutively in the Department of pathological anatomy and cytology of the University Hospital of Toulouse and included prospectively.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosis of Amyloidosis by Red Congo staining and birefringence in polarized light on tissue sampling
- •Immunolabeling Amyloidosis typing
- •impossible (no frozen sample available)
- •or inconclusive (doubtful)
- •or inconsistent with clinical, biological, genetic and iconographic data
- •Signature of the informed consent form
排除标准
- •Insufficient tissue material to perform the new technique
- •Person placed under judicial protection
- •Pregnant and breastfeeding women
研究组 & 干预措施
Amylose typing
Amyloidosis typing by nanoLC-MS/MS in patients diagnosed with Amyloidosis but unable to be typed
干预措施: Amyloidosis typing using mass spectrometry-based proteomics (Diagnostic Test)
结局指标
主要结局
Amyloidosis typing
时间窗: Day 0
Amyloidosis typing rate with the new technique
次要结局
- Time to return the result(Day 0)
- Concordance(Day 0)