Energy Intake and Energy Deficit in Obese Adolescents
- Conditions
- Pediatric Obesity
- Registration Number
- NCT03466359
- Lead Sponsor
- University Hospital, Clermont-Ferrand
- Brief Summary
The aim of the present study is to compare the effect of two weight loss interventions inducing the same energy deficit but one based on exercise and one using dietary restriction, on appetite control in obese adolescents. Investigator hypothesis that daily energy intake and hunger will be increased in the dietary restriction group but not in response to the exercise program.
- Detailed Description
The present study will compare the nutritional responses to two 4-month weight loss programs inducing the same energy deficit in obese adolescents, one based on exercise and the other one using dietary restriction. After a first 4-month phase stabilizing the adolescents' daily energy intake and expenditure, half of the sample with increase their physical activity to induce a 10% increase of their daily energy expenditure (maintaining the same energy intake) while the other half will stick with the same physical activity program but reduce their daily intake to match for the same 10% energy deficit. Before, at the end and 4 months after the intervention, Investigator will assess the adolescents' energy intake and appetite control by measuring: ad libitum energy intake, appetite feelings throughout the day, food preferences, food reward. But also all the potential underneath mechanisms based on gastro-peptides and adipokines. Finally, sleep metabolism will be assessed using polysomnography as a potential link between weight loss and appetite control. Body composition, quality of life, aerobic capacities and resting metabolic rate will also be measured at each time point.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 50
- BMI percentile > 97th percentile according to the french curves.
- ages 12-16 years old
- Signed consent form
- being registered in the national social security system
- no contraindication to physical activity
- Previous surgical interventions that is considered as non-compatible with the study.
- Diabetes
- weight loss during the last 6 months
- cardiovascular disease or risks
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Changes in energy intake at lunch time Before, after 10 months and 4 month after the intervention food intake will be measured ad libitum during a lunch time buffet. The adolescents will be offered an ad libitum buffet-type meal composed based on their food intake preferences. Their intake will be assessed by a member of the investigation team
- Secondary Outcome Measures
Name Time Method change in FM Before, after 10 months and 4 month after the intervention Fat mass (FM) was assessed using DXA following standardized procedures
Leptin concentration Before, after 10 months and 4 month after the intervention Leptin concentration will be assessed thanks to a fasting blood sample taken by a specialized nurse
appetite feelings Before, after 10 months and 4 month after the intervention hunger satiety will be assessed using visual analogue scale at regular interval through a test day
Quality of life Score Before, after 10 months and 4 month after the intervention A total Quality of life score will be obtain thanks to the "SF36" questionnaire. This is a self-reported questionnaire. A member of the investigation team will be present to help and guide the adolescents if needed
Health Perception Before, after 10 months and 4 month after the intervention A total Health Perception score will be obtain thanks to the "Health Perception Questionnaire ". This is a self-reported questionnaire. A member of the investigation team will be present to help and guide the adolescents if needed.
Glycaemia concentration Before, after 10 months and 4 month after the intervention glycaemia, will be assessed thanks to a fasting blood sample taken by a specialized nurse.
total cholesterol concentration Before, after 10 months and 4 month after the intervention. cholesterol total will be assessed thanks to a fasting blood sample taken by a specialized nurse.
LDL-C concentration Before, after 10 months and 4 month after the intervention LDL-C will be assessed thanks to a fasting blood sample taken by a specialized nurse.
Sleep metabolism Before, after 10 months and 4 month after the intervention sleep duration will be assessed during an overnight polysomnography.
HDL-C concentration Before, after 10 months and 4 month after the intervention HDL-C will be assessed thanks to a fasting blood sample taken by a specialized nurse
Triglycerides concentration Before, after 10 months and 4 month after the intervention Triglycerides concentration will be assessed thanks to a fasting blood sample taken by a specialized nurse.
Insulin concentration Before, after 10 months and 4 month after the intervention : Insulin will be assessed thanks to a fasting blood sample taken by a specialized nurse.
Acylated Ghrelin concentration Before, after 10 months and 4 month after the intervention Acylated Ghrelin concentration will be assessed thanks to a fasting blood sample taken by a specialized nurse
Aerobic capacity Before, after 10 months and 4 month after the intervention VO2peak will be measured during a graded exhaustive cycling test performed by a specialized medical investigator from the Department of Sports Medicine, Functional and Respiratory Rehabilitation (Clermont-Ferrand University Hospital). The initial power will be set at 30 W for three minutes and followed by 15 W increments every 1.5 minutes.
Trial Locations
- Locations (1)
CHU Clermont-Ferrand
🇫🇷Clermont-Ferrand, France