QL1706 With Olaparib for Previously Treated HER2-negative Breast Cancer Patients With Homologous Recombination Deficiency (HRD)

Not Applicable

Not yet recruiting

• Conditions: Previously Treated HER2-negative Breast Cancer Patients With Homologous Recombination Deficiency
• Interventions: Drug: QL1706 + olaparib

• Registration Number: NCT07113964
• Lead Sponsor: The First Affiliated Hospital with Nanjing Medical University

Brief Summary

This study will evaluate the safety and efficacy of QL1706 and Olaparib in human epidermal growth factor receptor 2 (HER2)-negative unresectable and/or metastatic breast cancer who had received 2-4 line of prior systematic therapy.

Detailed Description

Not available

Study Timeline

• Status Verified: 2025-07
• Study First Submitted: 2025-08-03
• Study First Submitted QC: 2025-08-03
• Last Update Submitted: 2025-08-03
• Study First Posted: 2025-08-11
• Last Update Posted: 2025-08-11
• Study Start: 2025-08-30
• Primary Completion: 2027-03-30
• Study Completion: 2029-03-30

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: Female
• Target Recruitment: 79

Inclusion Criteria

1. Age 18 - 75 years; Eastern Cooperative Oncology Group (ECOG) score status 0-1.
2. Pathologically documented HER2-negative locally advanced or metastatic breast cancer (IHC0, IHC 1+& IHC 2+/ISH-) that was hormone-receptor positive (i.e., estrogen-receptor positive, progesterone-receptor positive, or both) or was triple negative.
3. Has been treated with 2-4 previous therapy regimens for metastatic disease.
4. HRD positive confirmed, known germline and/or systemic BRCA mutation status that is predicted to be deleterious or suspected deleterious allow preferential enrolment.
5. At least 1 measurable lesion per Response Evaluation Criteria in Solid Tumors version 1.1.
6. Has protocol-defined adequate bone marrow, renal, hepatic and blood clotting functions.
7. A life expectancy of at least 12 weeks.
8. Female subjects of reproductive/childbearing potential must agree to use a highly effective form of contraception or avoid intercourse during and upon completion of the study and after the last dose for at least 3 months. Negative serum or urine pregnancy test within 7 days before study enrollment, and must be a non-lactating subject.
9. Volunteer to participate in this study and sign the informed consent.

Exclusion Criteria

1. Has any active autoimmune disease, which may worsen when receiving immune stimulants.
2. Prior treatment with immune checkpoint inhibitors (ICI) (anti-CTLA-4, anti-PD-1, anti-PD-L1, combined therapy anti-PD-1/PD-L1 with anti-CTLA-4) or olaparib for advanced disease.
3. Has unresolved toxicities from previous anticancer therapy.
4. Has uncontrolled or significant cardiovascular disease.
5. Discontinuation of prior anti-PD-1/PD-L1/CTLA-4 therapy due to immune-related toxicity.
6. Known history or evidence of interstitial lung disease or active non-infectious pneumonitis.
7. Has received a live vaccine vaccination within 28 days before enrolment.
8. Has a known history of human immunodeficiency virus (HIV) infection.
9. Has known history of or is positive for Hepatitis B or Hepatitis C.
10. Any severe or poorly controlled systemic disease such as poorly controlled hypertension, active bleeding susceptibility or active infection, as judged by the investigator.
11. Has untreated or clinically active central nervous system metastases.
12. Female subjects who are pregnant, lactating or plan to become pregnant during the study.
13. Has any other condition that per protocol or in the opinion of the investigator is inappropriate for the study.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Experimental:QL1706 + olaparib	QL1706 + olaparib	-

Primary Outcome Measures

Name	Time	Method
Progression-free Survival (PFS)	Up to approximately 3 years	PFS is defined as the time from the participant's first dose of study treatment to the first date of either disease progression or death, whichever occurs first.

Trial Locations

Locations (1)

The First Affiliated Hospital with Nanjing Medical University; 🇨🇳 Nanjing, Jiangsu, China