Defibrotide for Patients With Hepatic Veno-occlusive Disease: A Treatment IND Study
- Registration Number
- NCT00628498
- Lead Sponsor
- Jazz Pharmaceuticals
- Brief Summary
Single arm, open-label study to provide Defibrotide to patients diagnosed with VOD. Defibrotide is no longer available though the Emergency Use IND mechanism (also known as compassionate use, or single patient named use). This protocol is the only mechanism by which Defibrotide can be made available to patients in the U.S.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 1206
Entry criteria include the following:
-
Clinical diagnosis of VOD, made by Baltimore Criteria, Modified Seattle Criteria, or biopsy proven:
1.1 Baltimore Criteria- Bilirubin ≥2 mg/dL and at least 2 of the following clinical findings:
- Ascites (radiographic or physical exam)
- Weight gain of ≥5% compared to the day of conditioning-- if this value is not available, the weight on the date of admission to the SCT unit may be used)
- Hepatomegaly; increased over baseline.
1.2 Modified Seattle Criteria: At least two of the following
- Bilirubin ≥2 mg/dL
- Ascites (radiographic or physical exam) and/or weight gain ≥5% above baseline weight (defined as weight on the first day of conditioning- if this value is not available, the weight on the date of admission to the SCT unit may be used)
- hepatomegaly increased over baseline
1.3 Patients that do not meet the Baltimore Criteria or Modified Seattle Criteria and have biopsy proven VOD are eligible.
-
Patient must also provide written informed consent.
- Use of any medication which increases the risk of hemorrhage is disallowed. Use of heparin or other anticoagulants is disallowed within 12 hours unless being used for routine central venous line management, fibrinolytic instillation for central venous line occlusion, intermittent dialysis or ultrafiltration of CVVH.
- Clinically significant uncontrolled acute bleeding, defined as hemorrhage requiring > 15 cc/kg of packed red blood cells (e.g., a pediatric patient weighing 20 kg and requiring > 300cc of packed red blood cells/24 hours, or an adult patient weighing 70 kg and requiring >3 units of packed red blood cells/24 hours) to replace blood loss, OR bleeding from a site which in the Investigator's opinion constitutes a potential life-threatening source (e.g. pulmonary hemorrhage or CNS bleeding), irrespective of amount of blood loss, at any point from the date of SCT through the date of severe VOD diagnosis.
- Hemodynamic instability as defined by a requirement for multiple pressors, or inability to maintain mean arterial pressure (for children: to maintain mean arterial pressure within 1 standard deviation of age-adjusted levels) with single pressor support.
- Woman who are pregnant.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Defibrotide Defibrotide Defibrotide 25 mg/kg day given in 4 divided doses approximately every 6 hours
- Primary Outcome Measures
Name Time Method Survival by Day+100 Post Stem Cell Transplant or Chemotherapy Day +100 from HSCT or 100 days from start of chemotherapy
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (125)
Children's Hospital of Alabama
🇺🇸Birmingham, Alabama, United States
Phoenix Children's Hospital
🇺🇸Phoenix, Arizona, United States
Mayo Clinic Cancer Center
🇺🇸Phoenix, Arizona, United States
Arizona Oncology
🇺🇸Scottsdale, Arizona, United States
University Medical Center
🇺🇸Tucson, Arizona, United States
University of Arkansas for Medical Services
🇺🇸Little Rock, Arkansas, United States
City of Hope Medical Center
🇺🇸Duarte, California, United States
The University of California, San Diego
🇺🇸La Jolla, California, United States
Loma Linda University
🇺🇸Loma Linda, California, United States
Long Beach Memorial Medical Center
🇺🇸Long Beach, California, United States
Scroll for more (115 remaining)Children's Hospital of Alabama🇺🇸Birmingham, Alabama, United States