Cohort Study of Clinical and Neuroimaging Characteristics for BPPV Patients in China
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- BPPV
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
- Enrollment
- 150
- Locations
- 1
- Primary Endpoint
- Differences between patients with BPPV and control group in brain structure
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
The main objective is to analyze the abnormality of physical condition, mental health and blood examination of the patients with benign paroxysmal positional vertigo (BPPV). Besides, the investigators aim to establish a database of BPPV based on multimodal magnetic resonance imaging data in the brain to identify high-risk patients with residual dizziness (RD) and systematically establish the comprehensive assessment system for the precise diagnosis, treatment and recovery of RD, optimize the tactics of BPPV management in China.
Detailed Description
This is an observational, longitudinal, and single-center study. Confirmed BPPV cases will complete the following programs before and after 1 and 6 months of treatment for exploring biological mechanism and predictive biomarkers of BPPV: 1) fill in the behavioral psychological scales, 2) submit blood samples at a local laboratory, 3) receive 3 times brain MRI scan. The healthy controls will complete the same programs as BPPV-group mentioned above only at the time of inclusion. The investigators will establish the brain MRI database containing neuropsychological scales and blood parameters of BPPV in China.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Confirmed diagnosis of BPPV/Healthy subjects who have not had BPPV
Exclusion Criteria
- •History of organic diseases in central nervous system and mental disorder, such as tumors, infections, depressive disorder, schizophrenia, etc. Claustrophobic
Outcomes
Primary Outcomes
Differences between patients with BPPV and control group in brain structure
Time Frame: baseline and 1 and 6 months
The changes of brain volume (mm3) are evaluated by structural MRI
Differences between two groups in brain function
Time Frame: baseline and 1 and 6 months
The changes of brain functional connectivity intensity are evaluated by functional MRI
Changes on vertigo symptoms
Time Frame: baseline and 1 and 6 months
Vertigo is also assessed with the Visual Vertigo Analogue Scale (VVAS)
Difference in blood markers between the two groups
Time Frame: baseline and 1 and 6 months
Inflammatory index in the blood sample is neutrophils/lymphocytes
Secondary Outcomes
- Differences in Sleep between the two groups(baseline and 1 and 6 months)
- Differences in cognition between the two groups(baseline and 1 and 6 months)
- Differences in executive function between the two groups(baseline and 1 and 6 months)
- Differences in verbal memory and working memory between the two groups(baseline and 1 and 6 months)
- Differences in Fatigue between the two groups(baseline and 1 and 6 months)
- Difference in anxiety between the two groups(baseline and 1 and 6 months)
- Differences in auditory attention between the two groups(baseline and 1 and 6 months)
- Difference in depression between the two groups(baseline and 1 and 6 months)