Glycemic Index, Obesity, Insulin Resistance and CVD Risk, Part 2
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 24
- 试验地点
- 1
- 主要终点
- Insulin sensitivity as measured by FS-IVGTT
研究概览
简要总结
This study will compare the physiological effects of two isoenergetic, nutrient-controlled diets that differ in glycemic index. The diets will be studied in obese adults in a 10-day crossover feeding trial.
详细描述
This study will compare the physiological effects of two isoenergetic, nutrient-controlled diets that differ in glycemic index. The diets will be studied in obese male adults in a 10-day crossover feeding trial. Hypothesis: Obese subjects will show improvements in clinical endpoints associated with risk for diabetes and cardiovascular disease (CVD) after consuming a controlled low (compared to high) glycemic index diet for 10 days. 1º endpoint: insulin sensitivity as measured by the modified Frequently Sampled Intravenous Glucose Tolerance Test (FSIVGTT). 2º endpoints: CVD risk factors; postprandial studies of oxidative stress; thermic effect of food.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- Single
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •age 18 to 35 years
- •BMI ≥ 27 ≤45 kg/m2
- •willingness to refrain from alcohol and caffeinated beverage consumption for duration of study
排除标准
- •major medical illness
- •an abnormal screening laboratory test
- •taking any prescription medications that might affect body weight
- •current smoking (1 cigarette during any of the last 7 days)
- •consuming special diets
结局指标
主要结局
Insulin sensitivity as measured by FS-IVGTT
次要结局
- CVD risk factors
- Postprandial studies of oxidative stress
- Thermic effect of food