Glycemic Index and CVD: a Crossover Feeding Study
- Conditions
- Obesity
- Registration Number
- NCT00141076
- Lead Sponsor
- Boston Children's Hospital
- Brief Summary
This study will compare the physiological effects of two isoenergetic, nutrient-controlled diets that differ in glycemic index. The diets will be studied in obese adults in a 10-day crossover feeding trial.
- Detailed Description
This study will compare the physiological effects of two isoenergetic, nutrient-controlled diets that differ in glycemic index. The diets will be studied in obese male adults in a 10-day crossover feeding trial. Hypothesis: Obese subjects will show improvements in clinical endpoints associated with risk for diabetes and cardiovascular disease (CVD) after consuming a controlled low (compared to high) glycemic index diet for 10 days. 1º endpoint: insulin sensitivity as measured by the modified Frequently Sampled Intravenous Glucose Tolerance Test (FSIVGTT). 2º endpoints: CVD risk factors; postprandial studies of oxidative stress; thermic effect of food.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 24
- age 18 to 35 years
- male
- BMI ≥ 27 ≤45 kg/m2
- willingness to refrain from alcohol and caffeinated beverage consumption for duration of study
- major medical illness
- an abnormal screening laboratory test
- taking any prescription medications that might affect body weight
- current smoking (1 cigarette during any of the last 7 days)
- consuming special diets
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method Insulin sensitivity as measured by FS-IVGTT
- Secondary Outcome Measures
Name Time Method CVD risk factors Postprandial studies of oxidative stress Thermic effect of food
Trial Locations
- Locations (1)
Brigham & Women's Hospital
🇺🇸Boston, Massachusetts, United States