Glycemic Index, Obesity, Insulin Resistance and CVD Risk, Part 2
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Obesity
- Sponsor
- Boston Children's Hospital
- Enrollment
- 24
- Locations
- 1
- Primary Endpoint
- Insulin sensitivity as measured by FS-IVGTT
- Status
- Completed
- Last Updated
- 15 years ago
Overview
Brief Summary
This study will compare the physiological effects of two isoenergetic, nutrient-controlled diets that differ in glycemic index. The diets will be studied in obese adults in a 10-day crossover feeding trial.
Detailed Description
This study will compare the physiological effects of two isoenergetic, nutrient-controlled diets that differ in glycemic index. The diets will be studied in obese male adults in a 10-day crossover feeding trial. Hypothesis: Obese subjects will show improvements in clinical endpoints associated with risk for diabetes and cardiovascular disease (CVD) after consuming a controlled low (compared to high) glycemic index diet for 10 days. 1º endpoint: insulin sensitivity as measured by the modified Frequently Sampled Intravenous Glucose Tolerance Test (FSIVGTT). 2º endpoints: CVD risk factors; postprandial studies of oxidative stress; thermic effect of food.
Investigators
Eligibility Criteria
Inclusion Criteria
- •age 18 to 35 years
- •BMI ≥ 27 ≤45 kg/m2
- •willingness to refrain from alcohol and caffeinated beverage consumption for duration of study
Exclusion Criteria
- •major medical illness
- •an abnormal screening laboratory test
- •taking any prescription medications that might affect body weight
- •current smoking (1 cigarette during any of the last 7 days)
- •consuming special diets
Outcomes
Primary Outcomes
Insulin sensitivity as measured by FS-IVGTT
Secondary Outcomes
- CVD risk factors
- Postprandial studies of oxidative stress
- Thermic effect of food