Volumetric Quantification of Epicardial Fat Using Semiautomated High Resolution Atrial CT Segmentation in Patients With Atrial Fibrillation Receiving Catheter Ablation
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Influence of epicardial adipose tissue (EAT) volume on 1 year arrhythmia recurrences after catheter ablation
研究概览
简要总结
The goal of this prospective observational study is to learn about the influence of epicardial fat on the success of catheter ablation in patients with atrial fibrillation.
详细描述
A volumetric quantification of epicardial fat is examined by dual source cardiac computet tomography in patients with paroxysmal or persistent atrial fibrillation prior to receiving their first catheter ablation for atrial fibrillation. After ablation the recurrence of arrhythmia is examined after 3 and 6 months respectively.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients with planned catheter ablation due to paroxysmal or persistent atrial fibrillation
- •written informed consent
- •planned computet tomography
排除标准
- •history of left atrial catheter ablation
- •minor patients or patients not capable of giving written informed consent
- •contraindication for computet tomography with contrast agents (e.g. allergy to contrast agents or relevant renal insufficiency or hyperthyreosis)
- •patients with congenital heart defects or history of cardial surgery
结局指标
主要结局
Influence of epicardial adipose tissue (EAT) volume on 1 year arrhythmia recurrences after catheter ablation
时间窗: measurement of epicardial fat at baseline; anamnestic and ECG-control of arrhythmia after 3, 6 and 12 months
influence of EAT volume quantified by volumetric CT segmentation on 1 year arrhythmia recurrences after catheter ablation for paraxysmal or persistent atrial fibrillation
次要结局
- associations between EAT and gender, BMI, cholesterol levels, body fat(measurement of epicardial fat at baseline; anamnestic and ECG-control of arrhythmia after 3, 6 and 12 months)
- associations between EAT and low voltage areas quantified by high density electroanatomical mapping(measurement of epicardial fat and catheter ablation at baseline)
- associations between EAT and left atrial wall thining(measurement of epicardial fat at baseline; anamnestic and ECG-control of arrhythmia after 3, 6 and 12 months)