AVA on the PICU and NICU: Feasibility study with children needing mechanical ventilatio
- Conditions
- respiratory problems and respiratory failure10046304
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 20
PICU:
uncomplicated mechanical ventilation:
FiO2 < 40%, PC < or equal to 15 cmH2O above PEEP, PEEP < or equal to 8 cmH2O and spontaneous breathing efforts;
- FiO2< 40%, PRVC with a pressure < 20 cmH2O and a tidal volume of 6-8 ml a kilo and spontaneous breathing efforts.
NICU:
10 neonates with uncomplicated mechanical ventilation.
- FiO2 < 30%, PC < 15 cmH2O above PEEP, PEEP < 6 cmH2O and spontaneous breathing efforts;
- Hemodynamical stable without inotropica
- Weight > 1250 grams or gestational age > 29 weeks
Exclusion criteria PICU:
- No consent of the parents;
- ECMO treatment;
- Other ventilator than the Servo-i
- Neurological disturbances: brain trauma, status epileptica, disturbance of the mitochondria with neurological problems
- Congenital defect of the diaphragm
- Esophagal atresia before surgery
- Extubation possible within 24 hour.;Exclusioncriteria NICU:
- No consent of the parents
- Hemodynamically instable
- Other ventilator than the Servo-i
- Intraventricular hemorrhage, asphyxia, seizure
- Sedation too deep, no spontaneous breathing efforts
- Extubation possible within 24 hour
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Primair study parameters<br /><br>Practical feasibility:<br /><br>• Is it easy to bring in the Edi catheter and is it easy to measure the length<br /><br>you need for a specific child?<br /><br>• Can you fix the Edi catheter well because of the risk of aspiration?<br /><br>• Is it possible to bring in an Edi catheter if there is already a enteral<br /><br>feeding tube (to the stomach) in situ? And does the other enteral feeding tube<br /><br>(located in duodenum) influence the EAdi signals?<br /><br>• Do we get a good EAdi signal on the Servo-i?</p><br>
- Secondary Outcome Measures
Name Time Method <p>Secondary study parameters<br /><br>• Do the peak pressures stay below 35 cm H2O and do the difference between peak<br /><br>and PEEP stays between 15 en 20 cm H2O above PEEP? This because of preventing<br /><br>ventilator induced lung injury<br /><br>• Is the EAdi signal decreasing when there is a high pressure support?<br /><br>• What is the effect on the Edi signal after we change from conventional<br /><br>ventilation to NAVA?<br /><br>• What is the procedure for decreasing the NAVA level?<br /><br>Comfort and sedation during NAVA ventilation:<br /><br>• How comfortable is the patient during NAVA ventilation? </p><br>