Investigation of the Effects of Wet Cupping Therapy on Immune Modulation, Pulmonary Function, and Quality of Life in Patients With Asthma
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 52
- Locations
- 1
- Primary Endpoint
- Change in FVC From Baseline to 2 Months
Study Overview
Brief Summary
This study evaluated the effects of wet cupping therapy on immune modulation, pulmonary function, and quality of life in adults with asthma. A total of 52 participants aged 30 to 55 years were allocated to either a control group or a wet cupping therapy group. Participants in the wet cupping therapy group received two sessions of wet cupping therapy, at baseline and one month later. Participants in both groups underwent clinical assessments at baseline and at two months. Pulmonary function, asthma-related quality of life, asthma control, dyspnea, fatigue, anxiety, and depression were assessed in both groups. Selected inflammatory markers were assessed only in the wet cupping therapy group.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- None
Eligibility Criteria
- Ages
- 30 Years to 55 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Adults aged 30 to 55 years.
- •Clinically diagnosed with asthma.
- •Asthma diagnosis established at least 6 months before enrollment.
- •No wet cupping therapy within the previous 2 months.
- •No herbal supplementation affecting asthma within the previous 2 months.
- •Able to cooperate with spirometry testing.
Exclusion Criteria
- •Presence of another chronic disease.
- •Hospitalization during the study period.
Arms & Interventions
Control Group
Participants in the control group underwent pulmonary function testing at baseline and at two months and completed the study assessment scales at baseline and at the end of the study.
Wet Cupping Therapy Group
Participants received wet cupping therapy twice during the two-month study period, with the first session at baseline and the second session one month later. Pulmonary function testing and study assessments were performed at baseline and at two months.
Intervention: Wet Cupping Therapy (Procedure)
Outcomes
Primary Outcomes
Change in FVC From Baseline to 2 Months
Time Frame: Baseline and 2 months
Forced vital capacity (FVC) was assessed by spirometry. Change from baseline to 2 months was evaluated.
Change in Asthma Quality of Life Questionnaire Score From Baseline to 2 Months
Time Frame: Baseline and 2 months
Asthma-related quality of life was assessed using the Asthma Quality of Life Questionnaire (AQLQ). Higher scores indicate better asthma-related quality of life.
Change in COPD and Asthma Fatigue Scale Score From Baseline to 2 Months
Time Frame: Baseline and 2 months
Fatigue was assessed using the COPD and Asthma Fatigue Scale. Higher scores indicate greater fatigue severity.
Change in FEV1 From Baseline to 2 Months
Time Frame: Baseline and 2 months
Forced expiratory volume in 1 second (FEV1) was assessed by spirometry. Change from baseline to 2 months was evaluated.
Change in FEV1/FVC Ratio From Baseline to 2 Months
Time Frame: Baseline and 2 months
The FEV1/FVC ratio was assessed by spirometry. Change from baseline to 2 months was evaluated.
Change in PEF From Baseline to 2 Months
Time Frame: Baseline and 2 months
Peak expiratory flow (PEF) was assessed by spirometry. Change from baseline to 2 months was evaluated.
Change in Systemic Immune-Inflammation Index (SII) in the Wet Cupping Therapy Group From Baseline to 2 Months
Time Frame: Baseline and 2 months
The Systemic Immune-Inflammation Index (SII) was calculated from peripheral blood cell counts using platelet, neutrophil, and lymphocyte values. SII was assessed only in the wet cupping therapy group. The change in SII from baseline to 2 months was evaluated as an indicator of systemic immune-inflammatory status.
Change in Systemic Inflammation Response Index (SIRI) in the Wet Cupping Therapy Group From Baseline to 2 Months
Time Frame: Baseline and 2 months
The Systemic Inflammation Response Index (SIRI) was calculated from peripheral blood cell counts using monocyte, neutrophil, and lymphocyte values. SIRI was assessed only in the wet cupping therapy group. The change in SIRI from baseline to 2 months was evaluated as an indicator of systemic inflammatory status.
Secondary Outcomes
- Change in Asthma Control Test Score From Baseline to 2 Months(Baseline and 2 months)
- Change in Modified Medical Research Council Dyspnea Scale Score From Baseline to 2 Months(Baseline and 2 months)
- Change in Hospital Anxiety and Depression Scale Scores From Baseline to 2 Months(Baseline and 2 months)
- Change in Eosinophil Level in the Wet Cupping Therapy Group From Baseline to 2 Months(Baseline and 2 months)
Investigators
TUBA ÖZDEMİR
Family Medicine Specialist
Medipol University