Transcranial Direct Current Stimulation (tDCS) Combined With Computerized Cognitive Addiction Therapy(CCAT) and, Electronic Follow-up for Methamphetamine(MA) Dependent Patients

Not Applicable

• Conditions: Electronic Health Records; Transcranial Direct Current Stimulation; Methamphetamine-dependence; Computerized Cognitive AddictionTherapy
• Interventions: Device: Sham Transcranial Direct Current Stimulation (tDCS); Device: Ture Transcranial Direct Current Stimulation (tDCS)

• Registration Number: NCT04139148
• Lead Sponsor: Shanghai Mental Health Center

Brief Summary

Transcranial direct current stimulation (tDCS) combined with computerized cognitive addiction therapy(CCAT) for methamphetamine(MA) dependent patients in voluntary drug rehabilitation center. Electronic medical systems were applied for drug related knowledge education, self-evaluation and outpatient follow-up reminder after intervention in order to reduce relapse behaviors.

Detailed Description

Not available

Study Timeline

• Study Start: 2019-02-01
• Study First Submitted: 2019-04-12
• Status Verified: 2019-10
• Study First Submitted QC: 2019-10-23
• Study First Posted: 2019-10-25
• Last Update Submitted: 2019-11-14
• Last Update Posted: 2019-11-18
• Primary Completion: 2020-12
• Study Completion: 2021-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Methamphetamine dependent patients with normal eyesight and hearing.

Exclusion Criteria

• any diagnosis of DSM-IV axis I diseases.
• any physical diseases which might influence cognitive function such as epilepsy, cerebrovascular disease or brain injury.
• negative behaviors or harm to others.
• cognitive enhance drug use history in last 6 months.
• other drug dependence(except nicotine).

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Sham tDCS Combined With CCAT	Sham Transcranial Direct Current Stimulation (tDCS)	Sham transcranial direct current stimulation (tDCS) intervention combined with computerized cognitive addiction therapy(CCAT) group, last 25 minutes per day for 4 weeks(5 days/week). Electronic follow-up for 6 month including only outpatient follow-up reminder every four weeks.
True tDCS Combined With CCAT	Ture Transcranial Direct Current Stimulation (tDCS)	Ture transcranial direct current stimulation (tDCS) intervention combined with computerized cognitive addiction therapy(CCAT) group, last 25 minutes per day for 4 weeks(5 days/week). Electronic follow-up for 6 month including drug knowledge every week, self-evaluation every two weeks and outpatient follow-up reminder every four weeks.

Primary Outcome Measures

Name	Time	Method
Change from Baseline cue-induced craving at 2 weeks	2 weeks	Participants were instructed to watch methamphetamine-related videos by VR and rate their level of craving after smelling and recalling the last time they engaged in drug use. Craving was assessed by visual analog scales (VAS), with 0 mm being "no craving"and 100 mm representing "most craving ever experienced for methamphetamine".
Change from Baseline cue-induced craving at 4 weeks	4 weeks	Participants were instructed to watch methamphetamine-related videos by VR and rate their level of craving after smelling and recalling the last time they engaged in drug use. Craving was assessed by visual analog scales (VAS), with 0 mm being "no craving"and 100 mm representing "most craving ever experienced for methamphetamine".

Secondary Outcome Measures

Name	Time	Method
response inhibition function	2 weeks，4 weeks	stop signal task
cognitive function	2 weeks，4 weeks	Chinese version of the CogState Battery was used to assess cognitive function.
Attention bias towards methamphetamine	2 weeks，4 weeks	A Chinese version of the MA addiction dot probe task (DPT) is used to evaluate the attention bias towards drugs.
reward-related function	2 weeks，4 weeks	Delay Discounting Task

Trial Locations

Locations (1)

Shanghai Mental Health Center; 🇨🇳 Shanghai, China