Prognostic Value of RXR-α in Cutaneous Squamous and Basal Cell Carcinoma
- Conditions
- Non-melanoma Skin Cancer
- Registration Number
- NCT05550766
- Lead Sponsor
- Sohag University
- Brief Summary
Vitamin D has a crucial role in cancer control and prevention.vitamin D receptor (VDR) and its heterodimer Retinoid X receptor (RXR) are equally important in the cell. This ligand (vitamin D) and receptors (VDR-RXR) complex together triggers downstream DNA damage response in the cell.
Retinoid receptors are a superfamily of nuclear receptors. The preferred receptor that attaches to VDR is RXR, with its subunits α, β and γ. RXR α is more frequent in the skin than other tissues, while β occurs in internal organs and γ is frequently related to neural disorders.
the investigator hopes to assess prognosis of SCC \& BCC by using RXR-α biomarker \& attempts to use it in the treatment.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- All
- Target Recruitment
- 50
- Squamous cell carcinoma and basal cell carcinoma.
- Incisional & excisional biopsies.
- All the studied cases include sufficient materials for the immunohistochemical study 4. Complete clinical data
- Patients with a history of preoperative chemotherapy and/or radiotherapy.
- Insufficient or tiny tissue biopsies.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Prognostic Value of RXR-α in Cutaneous Squamous and Basal Cell Carcinoma One or two days after staining sections with the marker. immuohistochemical expression of RXR-α in Squamous and Basal Cell Carcinoma
- Secondary Outcome Measures
Name Time Method