Comparison of Ibuprofen, Cyclobenzaprine, or Both for Acute Cervical Strain: A Randomized Clinical Trial
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 61
- 试验地点
- 1
- 主要终点
- Pain
研究概览
简要总结
The purpose of this study is to see whether the combination of a muscle relaxant and anti-inflammatory drug is more effective at relieving pain in patients with neck strains or whiplash than either of the two medications alone.
详细描述
Muscle relaxants have been used extensively for neck and back pain since muscle spasm is thought to play a role in the cycle of pain and spasm. However, prior studies have conflicting results regarding their additive effect when given in addition to analgesics such as the NSAIDs. Because they have the potential to lead to adverse events their efficacy should be clearly demonstrated before their routine use.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •neck pain within 24 hours of injury
排除标准
- •Children, allergy or contraindication to any of the study drugs
研究组 & 干预措施
Cyclobenzaprine
干预措施: Cyclobenzaprine (Drug)
Ibuprofen
干预措施: Ibuprofen (Drug)
Ibuprophen plus Cyclobenzaprine
干预措施: Ibuprofen plus Cyclobenzaprine (Drug)
结局指标
主要结局
Pain
时间窗: Daily for 1 week
Use of Rescue Medications
时间窗: 24 hours
the number of patients taking additional rescue medications beyond the study meds
次要结局
- Time to Resumption of Work(1 week)
- Resumption of Work or School(next day)