Comparison of Ibuprofen, Cyclobenzaprine, or Both for Acute Cervical Strain: A Randomized Clinical Trial
- Conditions
- Cervical Strain
- Interventions
- Registration Number
- NCT00790270
- Lead Sponsor
- Stony Brook University
- Brief Summary
The purpose of this study is to see whether the combination of a muscle relaxant and anti-inflammatory drug is more effective at relieving pain in patients with neck strains or whiplash than either of the two medications alone.
- Detailed Description
Muscle relaxants have been used extensively for neck and back pain since muscle spasm is thought to play a role in the cycle of pain and spasm. However, prior studies have conflicting results regarding their additive effect when given in addition to analgesics such as the NSAIDs. Because they have the potential to lead to adverse events their efficacy should be clearly demonstrated before their routine use.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 61
- neck pain within 24 hours of injury
- Children, allergy or contraindication to any of the study drugs
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Ibuprofen Ibuprofen - Ibuprophen plus Cyclobenzaprine Ibuprofen plus Cyclobenzaprine - Cyclobenzaprine Cyclobenzaprine -
- Primary Outcome Measures
Name Time Method Pain Daily for 1 week Use of Rescue Medications 24 hours the number of patients taking additional rescue medications beyond the study meds
- Secondary Outcome Measures
Name Time Method Time to Resumption of Work 1 week Resumption of Work or School next day number of patients resuming regular activity the day following enrollment.
Trial Locations
- Locations (1)
Stony Brook University
🇺🇸Stony Brook, New York, United States