Cerebrovascular Hemodynamics and Neurocognitive Outcome in Patients With Acute Respiratory Distress Syndrome.
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- ARDS
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
- Enrollment
- 66
- Locations
- 1
- Primary Endpoint
- COx
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
The acute respiratory distress syndrome (ARDS) is a life-threatening disease with functional impairment of the lung. It is characterized by an excessive inflammatory response of lung tissue, capillaries, and blood vessels and is associated with high mortality. Patients who survive the acute phase of this critical disease often suffer from long-term physical, psychological, and mental sequelae, as well as persistent cognitive deficits.
In healthy individuals, autoregulatory mechanisms of the intracranial blood vessels keep blood supply to the brain independent of fluctuations in systemic blood pressure. In the case of a serious illness, these mechanisms of autoregulation may be impaired, which may favor cerebral hypoperfusion. Impairment of cerebrovascular hemodynamics can lead to neuronal damage in short and long term.
The aim of this project is to investigate cerebrovascular autoregulation in adult patients with ARDS and to evaluate the cognitive outcome at 3, 6 and 12 months after discharge from the intensive care unit.
Investigators
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- •Pre-existing neurological diseases with known intracranial pathology
- •Cerebrovascular disorders, including hemodynamically relevant extracranial vascular stenoses
Outcomes
Primary Outcomes
COx
Time Frame: Assessment for 60 minutes per day during the acute phase of ARDS (maximum 14 days after ARDS onset).
Cerebral Oximetry Index (COx) as a moving correlation between arterial blood pressure and cerebral oximetry with a range from -1 to +1. A COx above 0.3 is defined as impaired cerebrovascular autoregulation. The minutes with COX above 0.3 will be assessed.
Secondary Outcomes
- The Short Form (36) Health Survey (SF-36)(3, 6 and 12 months after discharge from ICU.)
- Cognitive Failures Questionnaire (CFQ)(3, 6 and 12 months after discharge from ICU.)