Prospective clinical study to investigate whether Crohn's disease, ulcerative colitis, multiple sclerosis and systemic scleroderma are associated with an increased prevalence of periodontitis

Recruiting

Conditions: K50.0
K50.1
G35.0
K51.0
M34.0
K05.3
Crohn disease of small intestine
Crohn disease of large intestine
Ulcerative (chronic) pancolitis
Progressive systemic sclerosis

Registration Number: DRKS00022956

Lead Sponsor: Mund-Kiefer- und Gesichtschirurgische KlinikFAU Uniklinik Erlangen

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 80

Inclusion Criteria

Patient suffers from scleroderma, Crohn's disease, ulcerative colitis or multiple sclerosis
Full age patients
Initial examination for periodontitis

Exclusion Criteria

Patient is already undergoing periodontal treatment
Smokers and diabetics, as these are additional risk factors for periodontitis
Poor general condition that does not allow for dental diagnostics (retardation, dementia)

Study & Design

Study Type: observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Is there an increased prevalence of periodontitis in SSc/CED/MS<br><br><br>RNA isolation in the laboratory using the trizole method and analysis of different markers (MMP 9 and 2, CD90,CD34 as well as interleukins IL-2,6 and 10)<br>Shock freeze the sample in liquid nitrogen after collection. Storage of the samples at -80°C

Secondary Outcome Measures

Name	Time	Method
Clinical parameters that correlate with disease and PA<br><br>Probe Depths PD (6 pages); Cardontal Screening Index PSI<br>O: <3.5mm PD, no BOP, PI 0<br>1: <3,5mm PD, BOP, PI 0<br>2:<3.5mm PD, BOP, PI 1<br>3: >3,5mm PD up to 5,5mm<br>4:>5,5mm<br>Bleeding on probing BOP<br>Suppuration<br>Recession<br>Percussion<br>Clinical Attachemia Loss CAL<br>Degree of loosening<br>Plaque Index according to Mombelli (PI)<br>Grade 0: no plaque detectable by inspection and probing<br>Grade 1: Accumulation of plaque, which is only visible by probing the sulcus with a probe but not with the eye<br>Grade 2: visible plaque deposition<br>Grade 3: massive plaque accumulation<br><br>unique presentation and collection of parameters, no further presentation necessary