ChronoMet: Metabolic and Inflammatory Effects of Eating Timing and Quantity
- Conditions
- Healthy Volunteers
- Interventions
- Dietary Supplement: Meals
- Registration Number
- NCT06161337
- Lead Sponsor
- University of Minnesota
- Brief Summary
This is an observational study to address the important knowledge gap of the metabolic and inflammatory impact of acute overeating and whether timing of acute overeating may modify these effects. The hypothesis is that acute overconsumption of calories will promote inflammation and metabolic dysfunction, with the most detrimental effects observed with evening caloric overconsumption. The expectation is that this study to provide critical insights into the biological consequences of overeating, which will direct novel approaches combating overeating and its detrimental health effects.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 60
- ages of 18-65 years old
- not pregnant
- no comorbid conditions
- normal BMI (18.5 - 24.9 kg/m2)
- Weight ≥120 lbs self-reported weight
- N/A
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Experimental group Meals 60 young (age 18-65), healthy, normal body mass index subjects for this study.
- Primary Outcome Measures
Name Time Method Inflammatory markers quantification 8 months employ a the MILLIPLEX ® Human Cytokine/Chemokine Multiplex Assay Panel to quantify 50 specific inflammatory markers in the serum samples.
quantitative metabolomics on serum samples 8 months leverage the University of Minnesota Center for Metabolomics and Proteomics to conduct analysis of serum samples utilizing the Biocrates MxP Quant 500, which provides detailed quantification of over 500 individual metabolites.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
University of Minnesota
🇺🇸Minneapolis, Minnesota, United States