The Effects of CUrcuminoids on Coronary Artery byPass graftIng-related myocarDial Infarction Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Incidence of postoperative myocardial infarction
研究概览
简要总结
It is well-established that myocardial infarction (MI) associated with coronary artery bypass graft surgery (CABG) predicts the poor outcome. Nevertheless, the cardioprotective therapies to limit myocardial injury after CABG are lacking. Previous studies have shown that curcuminoids suppress pro-inflammatory cytokines during cardiopulmonary bypass surgery and decrease the occurrence of cardiomyocytic apoptosis after cardiac ischemia/reperfusion injury in animal models. The investigators aim to evaluate whether curcuminoids prevent MI after CABG, compared to placebo.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients undergoing CABG without valve surgery
排除标准
- •emergency cardiac surgery
- •any increase in CK-MB above upper limit of normal range (ULN) at the time of randomization
- •patients with cholestatic jaundice (total bilirubin > 2-fold ULN)
- •severe liver disease (AST or ALT > 3-fold ULN)
研究组 & 干预措施
Curcuminoids
干预措施: Curcuminoids (Dietary Supplement)
Placebo
干预措施: Placebo (Other)
结局指标
主要结局
Incidence of postoperative myocardial infarction
时间窗: participants will be followed for the duration of hospital stay, an expected average of 10 days
次要结局
未报告次要终点
研究者
Wanwarang Wongcharoen, MD.
Principal investigator
Thailand Research Fund