Effectiveness of Oleanolic Acid as Intracanal Medicament on Infectious/Inflammatory Contents in Teeth With Apical Periodontitis
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 36
- 试验地点
- 1
- 主要终点
- Relief of signs and symptoms of apical periodontitis
研究概览
简要总结
The objective of this study is to investigate "clinically" the effectiveness of Oleanolic acid based intracanal medicament compared to the commonly used intracanal medicaments (Calcium hydroxide and Ledermix) on the levels of bacteria in root canals and inflammatory cytokines in the periradicular tissues of teeth with apical periodontitis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Single rooted teeth with pulp necrosis and apical periodontitis.
- •The age ranges from 20 to 60 years.
排除标准
- •Patient receiving antibiotic treatment within the preceding 3 months.
- •Patient reporting systemic disease.
- •Teeth that can not be isolated with rubber dam.
- •Teeth with periodontal pockets deeper than 3 mm.
研究组 & 干预措施
Calcium hydroxide group
After biomechanical preparation of the canals, calcium hydroxide intracanal medicament will be placed inside the canal for one week before obturation.
干预措施: Root canal treatment (Procedure)
Ledermix group
After biomechanical preparation of the canals, Ledermix intracanal medicament will be placed inside the canal for one week before obturation.
干预措施: Root canal treatment (Procedure)
Oleanolic acid group
After biomechanical preparation of the canals, Oleanolic acid intracanal medicament will be placed inside the canal for one week before obturation.
干预措施: Root canal treatment (Procedure)
结局指标
主要结局
Relief of signs and symptoms of apical periodontitis
时间窗: 1 Week
Absence of discomfort with percussion, Absence of inflammatory exudate from the root canal.
Decrease in bacterial count within the root canal.
时间窗: 1 week
A sample will be taken from the canal to assess the decrease in bacterial count inside the root canal by the effect of intracanal medicament.
Decrease in interleukin TNF-alpha, IL-1 Beta and PG-E2 in the periapical tissues
时间窗: 1 week
A sample will be taken from the periapical region to detect the effect of the intracanal medicaments in reducing inflammation and promoting healing in the periapical region.
次要结局
未报告次要终点