The Neutrophil-to-lymphocyte Ratio (NLR) and Platelet-to-lymphocyte Ratio (PLR) Levels Following IPACK Block in Knee Arthroplasty: a Randomized, Controlled Trial.
Trial Snapshot
- Phase
- Phase 4
- Status
- Completed
- Sponsor
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- Neutrophil-to-lymphocyte ratio
Study Overview
Brief Summary
Effect of iPACK block on NLR and PLR following knee arthroplasty
Detailed Description
The NLR is a sensitive indicator of inflammation confirmed in numerous studies and has a predictive and prognostic value. NLR is a cheap, simple, fast-acting, readily available stress and inflammation parameter with high sensitivity and low specificity. Dynamic changes in the NLR precede the clinical state for several hours and may alert clinicians early about the ongoing pathological process. NLR is a new promising marker of cellular immune activation, an important indicator of stress and systemic inflammation. It opens a new dimension for clinical medicine to understand better the biology of inflammation, the linkage, and antagonism between innate and adaptive immunity, and its clinical consequences for health and disease.
NLR is affected not only by surgical trauma but also by the method of anesthesia. In recent years, the influence of regional anesthesiology on reducing the inflammatory response after surgical procedures has been emphasized. However, there have been very few studies evaluating the effect of various methods of anesthesia on the NLR.
This is the first study to investigate the effect of regional anesthesia on the NLR and PLR in patients undergoing knee replacement surgery.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- Triple (Participant, Care Provider, Investigator)
Eligibility Criteria
- Ages
- 20 Years to 90 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Patients with ASA classification I-III
- •Aged 20-90 years
- •Who will be scheduled for hip arthroplasty under spinal anesthesia
Exclusion Criteria
- •Patients who have a history of bleeding diathesis
- •Take anticoagulant therapy
- •History of chronic pain before surgery
- •Multiple trauma
- •patients unable to assess their pain (dementia)
- •patients operated under general anesthesia
- •patients having an infection in region of the procedure
- •patient who do not accept the procedure
Arms & Interventions
Sham blocks
iPACK block with 20ml of 0.9% sodium chloride
Intervention: 0.9% Sodium Chloride Injection (Drug)
iPACK block
iPACK block with 20ml 0f 0.2% ropivacaine
Intervention: Ropivacaine 0.2% Injectable Solution (Drug)
Outcomes
Primary Outcomes
Neutrophil-to-lymphocyte ratio
Time Frame: 12 hours after surgery
Neutrophil to lymphocyte ratio (NLR) is used as a marker of subclinical inflammation. It is calculated by dividing the number of neutrophils by number of lymphocytes, usually from peripheral blood sample, but sometimes also from cells that infiltrate tissue, such as tumor.
Secondary Outcomes
- PLR(48 hours after surgery)
- NLR(48 hours after surgery)
- first need of opiate(48 hours after procedure)
- Opioid Consumption(48 hours after surgery)
- Pain score(48 hours after surgery)