Permian Health Women's Lung Health Study
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 350
- 试验地点
- 1
- 主要终点
- Prevalence of lung function Impairment as measured by spirometry
研究概览
简要总结
The goal of this cross-sectional observational study is to estimate the prevalence of lung function impairment as measured by spirometry in a population of Gambian women aged 15 and older. The main question[s] it aims to answer are:
- What is the prevalence of lung function impairment in Gambian women
- What is the prevalence of eosinophilic inflammation in Gambian women
Consenting participants will undergo
- Spirometry
- Fractional exhaled nitric oxide (FENO) testing
- α1-antitrypsin testing in patients with lung function impairment as assessed by spirometry
研究设计
- 研究类型
- Observational
- 观察模型
- Ecologic Or Community
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 15 Years 至 —（Child, Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Prevalence of lung function Impairment as measured by spirometry
时间窗: Through study completion, an average of 1 year
Certified technicians will perform Spirometry testing to measure lung function parameters such as FEV1, FVC, and FEV1/FVC ratio. Results will be interpreted by two Pulmonologists using GLI reference equations and z-scores. Bronchodilator reversibility is defined as an improvement of over 10% in FEV1 after albuterol sulfate administration. Lung function impairment will be assessed based on z-scores, with normal lung function being z-scores greater than -1.645, mild impairment between -1.65 and -2.5, moderate impairment between -2.51 and -4, and severe impairment below -4.1.
次要结局
- Prevalence of Type II (Eosinophilic) inflammation in Gambian Women(Through study completion, an average of 1 year)