midodrine effectiveness in patients who have low mean atrial pressure after open heart surgery
Phase 3
Recruiting
- Conditions
- CABG.Atherosclerosis of coronary artery bypass graft(s), unspecified, with angina pectoris with documented spasmI25.701
- Registration Number
- IRCT20201025049139N1
- Lead Sponsor
- Tehran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 100
Inclusion Criteria
More than 18 years old
Admitted in ICU
Systolic blood pressure less than 90 mmHg or mean atrial pressure less than 80 mmHg
Dependent to IV vassopressor
Received at least 24 hours IV vassopressor and can not discontinue it
Operation type is CABG
Exclusion Criteria
hypovolemia
septic shock
kidney failure (Cr>2mg/dl)
hepatic failure
electrolyte disturbance
pregnancy
tamponed
active bleeding
hypothyroid
hyperthyroid
midodrine allergy
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Blood pressure dependency rate to IV inotrope after midodrine initiation. Timepoint: study entrance time and 48 hours after that. Method of measurement: with Sphygmomanometer.;Intravenous vasopressor dose. Timepoint: after intravenous vasopressor discontinuation. Method of measurement: microgram.;ICU length of stay. Timepoint: after patient discharge from ICU. Method of measurement: according to hour.;Hospital length of stay. Timepoint: after patient discharge. Method of measurement: according to hour.;Left ventricular function. Timepoint: at the time of randomization. Method of measurement: echocardiography.;Creatinine. Timepoint: at the time of randomization. Method of measurement: in lab.
- Secondary Outcome Measures
Name Time Method