Comparison of the effect of intravenous and oral acetaminophen in the prevention of delirium
Phase 3
- Conditions
- Prevention of delirium in the elderly after heart surgery.Delirium due to known physiological condition
- Registration Number
- IRCT20211010052718N1
- Lead Sponsor
- Mazandaran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 64
Inclusion Criteria
Patients who are at least 60 years old and undergo heart surgery
Exclusion Criteria
Preoperative ventricular ejection fraction less than 30%
Emergency method
Aortic dissection surgery
Pre-existing cognitive dysfunction
Parkinson's disease
Alzheimer's disease
Recent seizures (less than 3 months), taking prophylactic medications for cognitive decline
Serum creatinine greater than 2 mg / dL
Liver dysfunction (liver enzymes more than four times basal)
Alcohol or drug abuse (more than 10 drinks per week)
Allergy to any of the studied drugs
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Delrium after surgery. Timepoint: The first 48 hours after surgery continue. Method of measurement: Visual Analogue Scale.
- Secondary Outcome Measures
Name Time Method The length of stay in the intensive care unit and hospital. Timepoint: After clearance. Method of measurement: Hospital file.