Comparison of enteral feeding versus no feeding in preterm babies less than 30 weeks of gestation on time to reach full feeds during the treatment of patent ductus arteriosus with oral Ibuprofen - DAFNI Trial

okmanyaTilak Municipal Medical College General Hospital Mumbai0 个研究点目标入组 126 人开始时间: 待定最近更新: 2022年10月17日

试验速览

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•All preterm babies less than 30 weeks of gestation with hemodynamically significant patent ductus arteriosus (PDA) on trearment with oral Ibuprofen.

•1.Contraindications for the use of ibuprofen (active bleeding, especially intracranial hemorrhage within 48 hours or gastrointestinal bleeding, thrombocytopenia(platelet count <60000/mm3, suspected NEC,significant impairment of renal function with serum creatinine > 1.5 mg/dl)
•2.Congenital heart disease in which patency of the ductus arteriosus is necessary for satisfactory pulmonary or systemic blood flow
•3.Major congenital anomalies.
•4.Chromosomal anomalies
•5.Congenital or acquired gastrointestinal anomalies
•6.Prior episodes of necrotizing enterocolitis or intestinal perforation
•7.Severe shock requiring > 2 Inotropes for hypotension at the time of entry
•8.Treatment of PDA after first week of life
•9.Babies on maximal enteral nutrition > 60 ml/kg/ day

发起方

okmanyaTilak Municipal Medical College General Hospital Mumbai