Randomised multicentre trial comparing bilateral subthalamic nucleus DBS and bilateral globus pallidus internus DBS for advanced Parkinson*s disease
Phase 3
Completed
- Conditions
- 10028037
- Registration Number
- NL-OMON30282
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 128
Inclusion Criteria
Inclusion criteria are idiopathic Parkinson's disease and * despite optimal pharmacological treatment * at least one of the following symptoms: severe response fluctuations, dyskinesias, painful dystonias, or bradykinesia.
Exclusion Criteria
Exclusion criteria are: age below 18 years, previous functional stereotactic neurosurgery, Hoehn and Yahr stage 5 at the best moment during the day, a MATTIS dementia rating scale score of 120 or less, current psychosis or depression, and contraindications for stereotactic neurosurgery such as a physical disorder making surgery hazardous (severe hypertension, blood coagulation disorder, severe dysphagia, or dysarthria).
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method