Study of the Expression of Heat Shock Proteins in Populations of B Lymphocytes in Human Tonsils
- Conditions
- Tonsillectomy
- Registration Number
- NCT02859090
- Lead Sponsor
- Centre Hospitalier Universitaire Dijon
- Brief Summary
It has recently been shown that various HSPs are strongly expressed in B lymphomas. Indeed, HSP90 stabilizes the protein Bcl-6 in diffuse large-cell B lymphomas. Pharmacological inhibition of HSP90 in vitro induced apoptosis in lymphoma cells (Cerchietti et al. Nat. Medicine, 2009, 1369-1376). In addition, HSP110 is strongly expressed in non-Hodgkin lymphomas, and targeting this HSP at the cell surface using specific antibodies could constitute a future therapy (Zappasodi et al. Blood, 2011, 4421-4430). Despite the importance of these proteins in the development of lymphomas, their expression and their role in the activation of normal B lymphocytes and the normal development of germinal centres is not known.
The expression of Heat shock proteins should vary among the different B lymphocyte populations present in the tonsils (naïve B cells, memory B cells, germinal centre B cells).
The aim of this study is to establish an expression profile for heat shock proteins in populations of B lymphocytes in human tonsils
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 5
- Persons who have provided oral consent
- Tonsillectomy in children or adults
- Persons without national health insurance cover
- Adults under guardianship
- Pregnant or breast-feeding women
- Persons with positive HIV or HCV serology
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method expression of heat shock proteins Day one
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
CHU Dijon Bourgogne
🇫🇷Dijon, France
CHU Dijon Bourgogne🇫🇷Dijon, France