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临床试验/NCT02546804
NCT02546804已完成不适用

Evaluate the Efficacy of Potassium Permanganate Mouthwash and Hot Salt Water Mouthwash and Their Comparison With Chlorhexidine Mouthwash on Plaque Index,Gingival Index and Periodontal Probing Depth

Government College of Dentistry, Indore1 个研究点 分布在 1 个国家目标入组 90 人开始时间: 2015年6月1日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
90
试验地点
1
主要终点
Plaque Index

研究概览

简要总结

Periodontal Disease is a ubiquitous in nature affecting about 80% population of India. The Periodontal Disease is a multifactorial but the dental plaque is considered as main etiological agent.The dental plaque, a adhesive bacterial coating accumulate around and in between teeth, if not removed by effective daily brushing and flossing, plaque can cause Gum infection and tooth loss. Though, many scientific periodontal procedures are available to get the treatment but because of lack of man power and poor socioeconomic condition it is not possible for every group of population in our India.

详细描述

The need exist for continued research to find the use of home made mouthwashes in preventing periodontal diseases. Although, Chlorhexidine mouthwash is regarded as Gold standard mouthwash as antiplaque but have some limitations like cost factor and side effects like staining of teeth, loss of taste, oral mucosal ulcerations,paresthesia and may enhanced supragingival calculus formation. Use of various indigenous products and home made preparations are easily available and are being used since ancient time in India and still in practice in various parts of India especially rural and remote areas.

At the same time the use of potassium permanganate is still in practice in various parts of India and also it was in practice before the availability of Chlorhexidine, povidone iodine and other antiseptic solutions, as they are used since about 30 years only. Use of hot salt water rinsing is in practice especially to reduce the symptoms of various throat infections such as pharyngitis, tonsillitis and also to improve oral hygiene.It is also being used in oral surgery and their effects are also mention in literature.

Hence, the aim of this study is to assess and compare the efficacy of home made remedies like hot salt water and potassium permanganate as a mouthwash in reducing Plaque accumulation and improving Gingival conditions with Gold standard Chlorhexidine mouthwash if found effective may be used as affordable mouthwash for the benefit of population of India.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Prevention
盲法
Double (Participant, Investigator)

入排标准

年龄范围
21 Years 至 55 Years(Adult)
性别
All
接受健康志愿者
是

入选标准

  • •Subject of Chronic Generalized Gingivitis and Mild Generalized Periodontitis.
  • •Not undergone any major periodontal treatment earlier in last 06 months .
  • •Otherwise Clinically Healthy Patient.

排除标准

  • •Subjects with significant systemic diseases (e.g. Diabetes Mellitus, Cancer or Coronary heart disease etc.).
  • •Pregnant or lactating women.
  • •Patients on anti-inflammatory drugs or antibiotics
  • •Patients allergic to any material used for the study

研究组 & 干预措施

HOT SALT WATER

Experimental

3% HOT SALT WATER , 25ml used for rinsing for 60 sec, twice daily for 60 days.

干预措施: HOT SALT WATER (Procedure)

CHLORHEXIDINE

Active Comparator

0.2% CHLORHEXIDINE, 10ml used for rinsing for 60 sec, twice daily for 60 days.

干预措施: CHLORHEXIDINE (Procedure)

POTASSIUM PERMANGANATE

Experimental

0.01% POTASSIUM PERMANGANATE, 10ml used for rinsing for 60 sec, twice daily for 60 days.

干预措施: POTASSIUM PERMANGANATE (Procedure)

结局指标

主要结局

Plaque Index

时间窗: baseline

4 sites of all tooth is observed

次要结局

  • Plaque Index(8weeks)
  • Periodontal Probing Depth(8weeks)
  • Gingival Index(8weeks)
  • Gingival Index(4weeks)
  • Plaque Index(4weeks)
  • Gingival Index(6weeks)
  • Periodontal Probing Depth(baseline)
  • Plaque Index(2weeks)
  • Plaque Index(6weeks)
  • Gingival Index(baseline)
  • Gingival Index(2weeks)
  • Periodontal Probing Depth(2weeks)
  • Periodontal Probing Depth(4weeks)
  • Periodontal Probing Depth(6weeks)

研究者

发起方
Government College of Dentistry, Indore
申办方类型
Other
责任方
Principal Investigator
主要研究者

Agrima Singh

P.G. Student

Government College of Dentistry, Indore

研究点 (1)

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