Effect of Multicomponent Exercise on Cognitive Function and Activities of Daily Living in People With Dementia
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Dementia
- Sponsor
- National Yang Ming Chiao Tung University
- Enrollment
- 52
- Primary Endpoint
- Mini-Mental State Examination
- Last Updated
- 4 years ago
Overview
Brief Summary
People with dementia shows a decline in cognition, such as memory, executive function (EF), language, attention, and spatial orientation that is significant enough to interfere with the independence and daily functioning. Previous studies reported that multicomponent exercise improved EF in people with mild cognitive impairment and independence of ADL in those with Alzheimer's disease. However, few studies investigated whether multicomponent exercise improved EF, memory, and ADL in people with dementia. Therefore, the purposes of this study are to examine 1) the effect of multicomponent exercise on EF, memory, and ADL in people with mild to moderate dementia; 2) the correlation between change in EF and ADL; 3) the correlation between change in memory and ADL.
Investigators
Yea-Ru Yang
Professor
National Yang Ming Chiao Tung University
Eligibility Criteria
Inclusion Criteria
- •Age: 60-80 y/o
- •Mini-Mental State Examination: 10-26
- •Clinical Dementia Rating: 1-2
- •Walk at least 6 meters independently (with or without walking aids)
Exclusion Criteria
- •Any other diagnosis of neurological diseases or musculoskeletal problems (Except dementia)
- •Physical or psychological comorbidities that affect performance during assessment or intervention
- •Already participating in other physical training in the last 1 month
Outcomes
Primary Outcomes
Mini-Mental State Examination
Time Frame: Change from baseline at 9 week
It is a 30-point questionnaire that is used extensively in clinical and research settings to measure cognitive impairment. Higher scores mean a better outcome.
Trail making test - Chinese version
Time Frame: Change from baseline at 9 week
It is a measurement to evaluate cognitive flexibility.
Chinese version of Stroop color and word test
Time Frame: Change from baseline at 9 week
It is a measurement to evaluate inhibition control.
Digit span test
Time Frame: Change from baseline at 9 week
It is a measurement to evaluate working memory.
Chinese version of Verbal learning test
Time Frame: Change from baseline at 9 week
It is a 9-point measurement to evaluate memory. Higher scores mean a better outcome.
Secondary Outcomes
- 30-second chair stand test(Change from baseline at 9 week)
- Berg Balance Scale(Change from baseline at 9 week)
- Time up and go test(Change from baseline at 9 week)
- Chinese version of Quality of Life in Alzheimer Disease Scale(Change from baseline at 9 week)
- 6-minute walk test(Change from baseline at 9 week)
- Barthel index(Change from baseline at 9 week)
- Instrumental activities of daily living (IADL) scale(Change from baseline at 9 week)