Abnormal fibre utilisation in ulcerative colitis in remissio
Not Applicable
Completed
- Conditions
- lcerative colitisUlcerative colitisOral and Gastrointestinal - Inflammatory bowel disease
- Registration Number
- ACTRN12614000271606
- Lead Sponsor
- Sally James
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 30
Inclusion Criteria
Age over 18 years
Diagnosis of ulcerative colitis, in remission
Healthy control inclusion criteria were age over 18 yrs, absence of bowel disease and absence of medication which affect bowel function and microbiota
Exclusion Criteria
Diagnosis of Crohn's disease, colectomy
Use of any of the following medication within the preceding 4 weeks, due to their effect on bowel and or microbial function:
Sulfasalazine, antibiotics, laxatives, topical rectal therapy, codeine or constipating drugs.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Composite primary outcome; <br>Faecal indices:<br>Faecal daily output, products of fermentation<br>Faecal starch and non-starch polysaccharide output<br>Microbial abundance <br><br>Faecal output was weighed, pH probed and SCFAs and Phenolic compounds measured with high performamce gas chromatography. Freeze dried faecal samples were analysed with commercial enzyme kits for residual fibres. Microbial abundances were tested with quantative polymerase chain reaction and denaturing gradient gel electrophoresis.<br><br>[After 7 days of usual diet (baseline), after each dietary intervention (after 17 days of supplementation with low or high amounts of fibre).]
- Secondary Outcome Measures
Name Time Method Clinical indices:<br>Tolerability of dietary supplements with regard to bowel symptoms was recorded on a 4 point Likert scale[At the end of each dietary intervention period (day 17 of each arm)];Whole gut transit time <br>Measured using radio-opaque markers x-rayed in 3 day faecal collection [Measured during the last 3 days of each observed period; baseline control period, and both intervention arms. ]