Preliminary Efficacy of a Digital Therapeutics Smartphone Application for Methamphetamine Use Disorder
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Methamphetamine Abuse
- Sponsor
- Adai Technology (Beijing) Co., Ltd.
- Enrollment
- 100
- Locations
- 1
- Primary Endpoint
- Cue induced craving for methamphetamine
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
One hundred participants were recruited and randomized into a digital therapeutics (DTx) group (n=52) and a treatment as usual (TAU) group (n=48). The DTx group used a smartphone application to deliver cognitive behavioral therapy, approach bias modification, cognitive training, and contingency management for eight weeks. The TAU group received counseling from social workers and psychoterapists. Cue-induced craving, cognitive functions, PHQ-9, and GAD-7 were measured at baseline and post-intervention.
Investigators
Eligibility Criteria
Inclusion Criteria
- •currently undergoing community-based rehabilitation were recruited voluntarily from four community
- •meeting Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) criteria for methamphetamine dependence.
Exclusion Criteria
- •could not fluently operate an Android or an iOS smartphone
- •having mental health conditions other than MUD
Outcomes
Primary Outcomes
Cue induced craving for methamphetamine
Time Frame: immediately after the intervetion
The cue-induced craving was assessed by showing the participants images related to methamphetamine (methamphetamine crystals, powders, and paraphernalia) on a smartphone and asking them to rate their cravings on a 0-10 visual analog scale (0 being least craved and 10 being most craved).
Cognitive Function Score
Time Frame: immediately after the intervetion
We use the Meaningless Figure Recognition Test (MFRT) to assess the cognitive function score. This test has eight blocks, and each block has two phases. In the first phase, the participant is presented with a series of meaningless figures one by one for three seconds. The participants were asked to memorize these figures. In the second phase, the previously presented meaningless figures and the same number of the novel meaningless figures are presented on one screen in random order. The participants were asked to recall their memory and click all the previously presented figures within 15 seconds. The correct rate of clicks is used for measuring the cognitive function scores.
Secondary Outcomes
- PHQ-9(immediately after the intervetion)
- GAD-7(immediately after the intervetion)