Mechanical Ventilation Parameters in HAP Patients

Completed

• Conditions: Mechanical Ventilation Pressure High
• Interventions: Device: mechanical ventilation

• Registration Number: NCT03111303
• Lead Sponsor: University Hospital Olomouc

Brief Summary

Hospital-acquired pneumonia (HAP) in patients in intensive care often requires the mechanical ventilation (MV). Management and weaning from MV are given by specificity of this type of pulmonary inflammation. Enrolled in the retrospective, observational study were all patients older than 18 years staying at the ICU of University Hospital in Olomouc, between 1 January 2011 and 31 December 2016. The determination of the parameters of the MV, ICU length of stay, hospital length of stay and mortality in HAP group were compared with the control group of patients without HAP.

Detailed Description

Hospital-acquired pneumonia (HAP) development influences the parameters of mechanical ventilation, intensive care unit (ICU) length of stay, hospital length of stay, need of tracheostomy, bronchoscopy, reconnection to MV and mortality. We respect HAP definition: acute inflammation of the respiratory bronchioles, alveolar structures and pulmonary interstitium. Clinically it is defined as the presence of newly developed or progressive infiltrates on chest radiographs plus at least two other signs of respiratory tract infection: temperature \>38 °C, chest pain, purulent sputum, leukocytosis or leukopenia, signs of inflammation on auscultation, cough and/or respiratory insufficiency. HAP is defined as pneumonia that occurs 48 hours or more after admission, which was not incubating at the time of admission. A retrospective, observational study processing data on all consecutive intensive care patients older than 18 years of age between 1 January 2011 and 31 December 2015. The aim was to determine the incidence of potential risk factors and their impact on the development of HAP. The primary outcome was investigation of the relationship between mechanical ventilation parameters and the presence of early- and late-onset HAP. Enrolled in the study were patients staying at the ICU of the Department of Anesthesiology and Intensive Care Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, between 1 January 2011 and 31 December 2016. The participants were all patients older than 18 years of age consecutively admitted to the ICU.

Study Timeline

• Study Start: 2011-01-01
• Primary Completion: 2016-12-31
• Study Completion: 2017-04-06
• Study First Submitted: 2017-04-07
• Study First Submitted QC: 2017-04-11
• Study First Posted: 2017-04-12
• Status Verified: 2017-10
• Last Update Submitted: 2017-10-24
• Last Update Posted: 2017-10-26

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 2654

Inclusion Criteria

• Age 18+
• Need of Mechanical ventilation (Pressure controlled mechanical ventilation or Pressure support ventilation)

Exclusion Criteria

• Organ donor
• Need Volume controlled mechanical ventilation
• no mechanical ventilation

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
HAP patients	mechanical ventilation	Mechanical ventilation, patients fulfilled HAP criteria
non HAP patients	mechanical ventilation	Mechanical ventilation, patients without HAP

Primary Outcome Measures

Name	Time	Method
length of mechanical ventilation	during MV	days of MV

Secondary Outcome Measures

Name	Time	Method
ICU length of stay	1 month	length of stay in ICU
Hospital length of stay (LOS)	1 month	length of hospital stay
Mortality	1 month	mortality during Hospital LOS