Exercise, Arterial Cross-Talk Modulation and Inflammation in an Ageing Population
- Conditions
- Heart; Disease, ActivityCardiovascular DiseaseObesityAtherosclerosis
- Interventions
- Other: Training or control condition
- Registration Number
- NCT02796976
- Lead Sponsor
- University of Basel
- Brief Summary
The aims of the study are twofold. In the cross-sectional approach (Part I), the study will be conducted in an older population to assess the association of physical fitness on different parts of the human vascular bed. In the interventional approach (Part II), it aims to investigate whether and to what extent advanced vascular ageing (AVA) in older subjects with increased cardiovascular risk can be reversed by regular walking- based high intensity interval training.
- Detailed Description
In the cross-sectional part the investigators analyze physical fitness, vascular health and further outcomes in a healthy older active, a healthy older sedentary and a obese sedentary group with increased cardiovascular risk. The investigators will analyze large and small artery function, physical fitness and activity as well as inflammatory parameters in these three groups. Here the investigators will investigate the influence of physical activity and inflammatory parameters on the vascular health in different beds.
In the intervention part the older sedentary group with increasing cardiovascular risk (OSR) will be randomized in a control and an intervention group. The intervention group will get a high intensity interval training which is walking based and individual adjusted. The control group will get general lifestyle recommendations. After 12 weeks of training OSR group will be tasted again. The aim of the second part is to assess the effect of high intensity interval training on vascular health and inflammatory parameters.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 158
- men and women aged 50-79 years
- Active lifestyle: > 9 MET/week (> 3hours moderate walking/week); 18.5≤ BMI ≤ 29.9 kg/m2
- Sedentary lifestyle: ≤ 3 MET/week (≤ 1 hour moderate walking/week); 18.5≤ BMI ≤ 29.9 kg/m2
- Sedentary men and women aged 50-79 years with increased cardiovascular risk are allowed to have ≥ one additional cardiovascular risk factor
- History of cardiovascular, pulmonary or chronic inflammatory disease
- blood pressure ≥ 140/90 mmHg during 24h monitoring
- current or past smoker (in healthy group)
- macular degeneration or glaucoma
- compromising orthopaedic problems
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description older sedentary at risk Training or control condition cross-sectional and training or control condition
- Primary Outcome Measures
Name Time Method Change of pulse wave velocity (m/s) Change from baseline pulse wave velocity at 12 weeks Measured at local, central and peripheral site
- Secondary Outcome Measures
Name Time Method Change of augmentation index (AIx@75) in % Change from baseline augmentation index at 12 weeks AIx and AIx@75 will be measured by using the gold standard device for single measurements (SphygmoCor®)
Change of arteriolar to venular diameter ratio (AVR) in µm Change from baseline AVR at 12 weeks Dynamic and static retinal vessel analyzes will be investigated
Change of physical activity in METs per week Change from baseline physical activity at 12 weeks The Freiburger Questionnaire of physical activity and inactivity and an accelerometer for seven days will be used to measure physical activity.
Change of physical fitness in VO2max Change from baseline VO2max at 12 weeks An individual treadmill ramp test will be used to investigate peak oxygen consumption and maximal heart rate.
Trial Locations
- Locations (1)
Bereich Sport- und Bewegungsmedizin, Abteilung Präventive Sportmedizin & Systemphysiologie
🇨🇭Basel, Basel Stadt, Switzerland