Clinical Characteristics and Molecular Mechanism of Patients With Obstructive Sleep Apnea
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 500
- 试验地点
- 1
- 主要终点
- Multiple-omics features
研究概览
简要总结
To clarify the clinical features of patients with obstructive sleep apnea; To construct a multi-omics database of patients with obstructive sleep apnea, and compare the effects of different degrees of sleep apnea on prognosis, immunity, and metabolism. The medium and long-term prognosis, complications, comorbidities, risk factors, and immune and metabolic dynamics of patients with sleep apnea after treatment were studied. To elucidate the biomarkers and therapeutic targets associated with obstructive sleep apnea.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients with suspected obstructive sleep apnea (OSA) admitted to the sleep center of the respiratory Department of Beijing Chaoyang Hospital, Capital Medical University.
- •Volunteer to participate in the study and sign an informed consent, and can complete at least 1 year of follow-up.
排除标准
- •Patients with obstructive sleep apnea who have been treated with impermanent positive pressure ventilation;
- •Pregnant or lactating women;
- •Patients with severe respiratory failure requiring mechanical ventilation;
- •Patients with severe heart, lung, liver, kidney, and central nervous system damage;
- •Refuse to participate in follow-up visits and/or take biological samples.
结局指标
主要结局
Multiple-omics features
时间窗: Within 24 hours of admission，and samples of patients receiving treatment were also collected six months and one year after treatment
ELISA ,proteomics and metabolomics were performed on blood, saliva, urine
次要结局
未报告次要终点
研究者
Zhaohui Tong
professor
Beijing Chao Yang Hospital