A Study to Investigate the Efficacy and Safety of Efgartigimod PH20 SC in Adult Participants With Active Idiopathic Inflammatory Myopathy.
- Conditions
- Active Idiopathic Inflammatory MyopathyMyositisDermatomyositisPolymyositisImmune-Mediated Necrotizing MyopathyAntisynthetase Syndrome
- Interventions
- Other: PBO
- Registration Number
- NCT05523167
- Lead Sponsor
- argenx
- Brief Summary
This study's purpose is to measure the treatment response from efgartigimod PH20 SC compared with placebo in participants with Idiopathic Inflammatory Myopathy (IIM). Participants with the IIM subtypes of dermatomyositis (DM), immune-mediated necrotizing myopathy (IMNM), or certain other subtypes of polymyositis (PM; including antisynthetase syndrome \[ASyS\]) will be included in the study. Treatment response will be measured by Total improvement score (TIS). Additional information can be found on https://myositis-study.com/.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 240
- Ability to consent in the jurisdiction in which the study is taking place and capable of giving signed informed consent.
- A definite or probable clinical diagnosis of idiopathic inflammatory myopathy (IIM)
- One of the following medical histories: Diagnosis of dermatomyositis (DM) or juvenile dermatomyositis (JDM), Diagnosis of polymyositis (PM) (including antisynthetase syndrome (ASyS)), Diagnosis of immune-mediated necrotizing myopathy (IMNM)
- Diagnosed with active disease as defined by the presence of at least 1 of the following criteria: Abnormal levels of at least 1 of the following enzymes: creatine kinase (CK), aldolase, lactate dehydrogenase, aspartate aminotransaminase (AST), alanine aminotransferase (ALT), based on central laboratory results; Electromyography demonstrating active disease within the past 3 months; Active dermatomyositis (DM) skin rash; Muscle biopsy indicative of active idiopathic inflammatory myopathy (IIM) in the past 3 months; Magnetic resonance imaging within the past 3 months indicative of active inflammation
- Muscle weakness
- Receiving a permitted background treatment for idiopathic inflammatory myopathy.
- Contraceptive use consistent with local regulations, where available, for individuals participating in clinical studies. Women of childbearing potential must have a negative serum pregnancy test during screening and a negative urine pregnancy test at baseline before receiving investigational medicinal product (IMP).
The full list of inclusion criteria can be found in the protocol.
- A clinically significant active infection at screening
- A COVID-19 polymerase chain reaction (PCR)-positive test before enrollment
- Any other known autoimmune disease that, in the investigator's opinion, would interfere with an accurate assessment of clinical symptoms of idiopathic inflammatory myopathy (IIM) or put the patient at undue risk
- A history of malignancy unless considered cured by adequate treatment, with no evidence of recurrence for ≥ 3 years before the first administration of the investigational medicinal product (IMP). Adequately treated participants with the following cancers can be included at any time: Basal cell or squamous cell skin cancer ; Carcinoma in situ of the cervix; Carcinoma in situ of the breast; Incidental histological finding of prostate cancer
- Severe muscle damage
- Glucocorticoid-induced myopathy that the investigator considers the primary cause of muscle weakness or permanent weakness linked to a non-idiopathic inflammatory myopathy (IIM) cause
- Juvenile myositis (JDM) diagnosed > 5 years from screening or juvenile myositis with extensive calcinosis or severe calcinosis.
- Uncontrolled interstitial lung disease or any other uncontrolled idiopathic inflammatory myopathy (IIM) manifestation that, in the opinion of the investigator, would be likely to require treatment with prohibited medication during the study
- Other inflammatory and noninflammatory myopathies: inclusion body myositis, overlap myositis), metabolic myopathies, muscle dystrophies or a family history of muscle dystrophy, drug-induced or endocrine induced myositis, and juvenile myositis (other than juvenile dermatomyositis (JDM))
- Clinically significant disease, recent major surgery or intends to have surgery during the study, or has any other condition in the opinion of the investigator that could confound the results of the trial or put the patient at undue risk
- Known hypersensitivity reaction to investigational medicinal product (IMP) or 1 of its excipients
- Received a live or live-attenuated vaccine less than 4 weeks before screening.
- Positive serum test at screening for active viral infection with any of the following conditions: Hepatitis B virus (HBV); Hepatitis C virus (HCV); HIV
- Participant has previously participated in an efgartigimod clinical trial and received at least 1 dose of investigational medicinal product (IMP).
- Participant is concurrently participating in any other clinical study, including a noninterventional study.
- Participant has a current or history (ie, within 12 months of screening) of alcohol, drug, or medication abuse.
- Participant is pregnant or lactating or intends to become pregnant during the study.
- Participant has severe renal impairment .
- Participant is institutionalized by a court or other governmental order or is in a dependent relationship with the sponsor or investigator.
The full list of exclusion criteria can be found in the protocol.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description EFG PH20 SC EFG PH20 SC participants receiving efgartigimod PH20 SC on top of background treatment PBO PH20 SC PBO participants receiving placebo PH20 SC on top of background treatment
- Primary Outcome Measures
Name Time Method Total improvement score (TIS); measured on a [0,100] scale. Higher scores represent improvement; zero indicates no improvement or worsening (from baseline). phase 2: 24 weeks; phase 3: 52 weeks
- Secondary Outcome Measures
Name Time Method Time to reach TIS ≥ 20 (first "minimal clinical improvement") phase 2: up to 24 weeks; phase 3: up to 52 weeks Percentage of participants with TIS ≥ 20 phase 2: 24 weeks; phase 3: 52 weeks Time to reach TIS ≥ 40 (first "moderate clinical improvement") phase 2: up to 24 weeks; phase 3: up to 52 weeks Percentage of participants with TIS ≥ 40 phase 2: 24 weeks; phase 3: 52 weeks Change in manual muscle testing-8 (MMT8) score phase 2: 24 weeks; phase 3: 52 weeks Change in Patient Global Assessment of Disease Activity (PGA) phase 2: 24 weeks; phase 3: 52 weeks Change in Physician Global Assessment of Disease Activity (MDGA) phase 2: 24 weeks; phase 3: 52 weeks Proportion of participants achieving target dose of ≤ 5 mg (prednisone equivalent) Phase 3: 52 weeks
Trial Locations
- Locations (213)
The University of Tokyo Hospital
🇯🇵Tokyo, Japan
Universitatsklinikum Ulm - Standort Oberer Eselsberg
🇩🇪Ulm, Germany
Juntendo University Hospital - Rheumatology
🇯🇵Tokyo, Japan
Institute of Rheumatology
🇷🇸Belgrad, Serbia
Narodny ustav reumatickych chorob
🇸🇰Piešťany, Slovakia
Hospital General Universitario de Alicante
🇪🇸Alicante, Spain
Allgemeines Krankenhaus der Stadt Wien (AKH Wien)
🇦🇹Wien, Austria
AZ Sint Lucas Gent-Campus Sint Lucas
🇧🇪Gent, Belgium
Universitaetsklinikum Tuebingen (UKT)
🇩🇪Tuebingen, Germany
Fiona Stanley Hospital
🇦🇺Murdoch, Australia
Tokyo Medical And Dental University Hospital, Faculty of Medicine
🇯🇵Bunkyo-ku, Japan
Japan Community Healthcare Organization Chukyo Hospital
🇯🇵Nagoya, Japan
Neuromuscular Research Center
🇺🇸Phoenix, Arizona, United States
HonorHealth Neurology - Bob Bove Neuroscience Institute - Neurology
🇺🇸Scottsdale, Arizona, United States
Attune Health Research, Inc
🇺🇸Beverly Hills, California, United States
Profound Research LLC - Oceanside
🇺🇸Oceanside, California, United States
University of California, Irvine
🇺🇸Orange, California, United States
Eisenhower Medical Center
🇺🇸Rancho Mirage, California, United States
University of Tsukuba Hospital - Rheumatology
🇯🇵Tsukuba-shi, Japan
Stanford Medicine Outpatient Center - Stanford Dermatology Clinic-Stanford University School of Medicine
🇺🇸Redwood City, California, United States
California Pacific Medical Center - Sutter Health
🇺🇸San Francisco, California, United States
Amyotrophic Lateral Sclerosis (ALS) Treatment Center,University of California San Francisco (UCSF)
🇺🇸San Francisco, California, United States
Denver Arthritis Clinic
🇺🇸Denver, Colorado, United States
Yale Cancer Center-Yale University School Of Medicine
🇺🇸New Haven, Connecticut, United States
Medical University Innsbruck
🇦🇹Innsbruck, Austria
Georgetown University Hospital
🇺🇸Washington, District of Columbia, United States
UF Health Rheumatology
🇺🇸Gainesville, Florida, United States
University of South Florida (USF) - Morsani Center (USF Health Carol and Frank Morsani Center for Advanced Healthcare)
🇺🇸Tampa, Florida, United States
Emory University Hospital, The Emory Clinic
🇺🇸Atlanta, Georgia, United States
Augusta University
🇺🇸Augusta, Georgia, United States
Northwestern Memorial Hospital
🇺🇸Chicago, Illinois, United States
University Of Kansas Medical Center
🇺🇸Kansas City, Kansas, United States
Johns Hopkins Medicine - Johns Hopkins Myositis Center
🇺🇸Baltimore, Maryland, United States
Harvard Medical School - Brigham and Women's Hospital (BWH) - The Schuster Family Transplantation Research Center (TRC)
🇺🇸Boston, Massachusetts, United States
Michigan State University - Neurology
🇺🇸East Lansing, Michigan, United States
St. Paul Rheumatology, PA
🇺🇸Saint Paul, Minnesota, United States
Northwell Health
🇺🇸Great Neck, New York, United States
Hospital for Special Surgery
🇺🇸New York, New York, United States
University of North Carolina (UNC) School of Medicine
🇺🇸Chapel Hill, North Carolina, United States
Carolina Arthritis Associates
🇺🇸Wilmington, North Carolina, United States
Cleveland Clinic - Main Campus
🇺🇸Cleveland, Ohio, United States
The Ohio State University
🇺🇸Columbus, Ohio, United States
Oregon Health and Science University
🇺🇸Portland, Oregon, United States
University of Pittsburg Medical Center
🇺🇸Pittsburgh, Pennsylvania, United States
Vanderbilt University Medical Center (VUMC) - Vanderbilt Rheumatology Clinic
🇺🇸Nashville, Tennessee, United States
Austin Neuromuscular Center
🇺🇸Austin, Texas, United States
McGovern Medical School -The University of Texas Health Science Center at Houston
🇺🇸Houston, Texas, United States
Nerve And Muscle Center Of Texas
🇺🇸Houston, Texas, United States
University of Vermont Medical Center - Main Campus
🇺🇸Burlington, Vermont, United States
University of Washington Medical Center
🇺🇸Seattle, Washington, United States
Consultora Integral de Salud
🇦🇷Córdoba, Argentina
Framingham Centro Medico
🇦🇷La Plata, Argentina
Dim Clinica Privada
🇦🇷Ramos Mejía, Argentina
Centro de Investigaciones Medicas Tucuman
🇦🇷San Miguel De Tucumán, Argentina
Centro Dermatologico Schejtman
🇦🇷San Miguel, Argentina
The Wesley Medical Research
🇦🇺Auchenflower, Australia
Universitair Ziekenhuis Leuven Gasthuisberg Campus
🇧🇪Leuven, Belgium
Centre Hospitalier Universitaire Sart Tilman
🇧🇪Liège, Belgium
Medical Centre Artmed
🇧🇬Plovdiv, Bulgaria
Multiprofile hospital for active treatment Kaspela EOOD
🇧🇬Plovdiv, Bulgaria
Genge Partners
🇨🇦Montréal, Canada
Ottawa Hospital Research Institute-Civic Campus
🇨🇦Ottawa, Canada
Cyprus Institute of Neurology and Genetics
🇨🇾Nicosia, Cyprus
Revmatologicky ustav
🇨🇿Praha, Czechia
Copenhagen University Hospital-Rigshospitalet University Hospital
🇩🇰Copenhagen, Denmark
Reference Center Neuro-Muscular Diseases - CHU Paris Group Hospitalier La Pitie Salpetriere-Charles Foix
🇫🇷Paris, France
Centre Hospitalier Universitaire (CHU) Hopitaux de Rouen
🇫🇷Rouen, France
Hopitaux Universitaire de Strasbourg-Centre de References des Maladies Autoimmunes
🇫🇷Strasbourg, France
American Hospital Network
🇬🇪Tbilisi, Georgia
LTD New Hospitals
🇬🇪Tbilisi, Georgia
Aversi Clinic
🇬🇪Tbilisi, Georgia
LLC MediClub Georgia
🇬🇪Tbilisi, Georgia
The First Medical Center
🇬🇪Tbilisi, Georgia
LTD Tbilisi Heart Center
🇬🇪Tbilisi, Georgia
Charite - Universitaetsmedizin Berlin - Campus Charite Mitte (CCM)
🇩🇪Berlin, Germany
Universitaetsklinikum Duesseldorf
🇩🇪Düsseldorf, Germany
Universitatsmedizin Gottingen - Georg-August-Universitat
🇩🇪Göttingen, Germany
Rheumazentrum Ruhrgebiet
🇩🇪Herne, Germany
Universitatsmedizin Mannheim
🇩🇪Mannheim, Germany
National and Kapodistrian University of Athens - School of Health Sciences - Faculty of Medicine
🇬🇷Athens, Greece
National and Kapodistrian University of Athens - Eginition Hospital
🇬🇷Athens, Greece
Attikon General University Hospital
🇬🇷Athens, Greece
Athens Medical Center
🇬🇷Athens, Greece
University of Ioannina Medical School
🇬🇷Ioánnina, Greece
Semmelweis Egyetem, Institute of Genomic Medicine and Rare Disorders
🇭🇺Budapest, Hungary
Debreceni Egyetem - University of Debrecen
🇭🇺Debrecen, Hungary
St. Vincents University Hospital
🇮🇪Dublin, Ireland
Connolly Hospital Blanchardstown
🇮🇪Dublin, Ireland
North West Rheumatology Unit - Our Lady's Hospital
🇮🇪Manorhamilton, Ireland
Bnai Zion Medical Center
🇮🇱Haifa, Israel
Rambam Health Care Campus
🇮🇱Haifa, Israel
Sheba Medical Center - Rheumatology
🇮🇱Ramat Gan, Israel
Azienda Ospedaliera Universitaria Policlinico Consorziale Di Bari - Rheumatology
🇮🇹Bari, Italy
Azienda Ospedaliero Universitaria Careggi
🇮🇹Firenze, Italy
Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) - Ospedale San Raffaele Hospital
🇮🇹Milan, Italy
San Matteo Hospital
🇮🇹Pavia, Italy
A.O. Universitaria Pisana
🇮🇹Pisa, Italy
IRCCS Arcispedale Santa Maria Nuova
🇮🇹Reggio Emilia, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Universita Cattolica del Sacro Cuore
🇮🇹Roma, Italy
Azienda Ospedaliero Universitaria Sant'Andrea
🇮🇹Roma, Italy
IRCCS Istituto Clinico Humanitas - Rheumatology
🇮🇹Rozzano, Italy
Azienda Ospedaliero Universitaria Citta della Salute e della Scienza di Torino - Presidio Molinette
🇮🇹Torino, Italy
ASU FC - Presidio Ospedaliero Universitario Santa Maria della Misericordia
🇮🇹Udine, Italy
Azienda Ospedaliera Universitaria Integrata di Verona - Ospedale Borgo Roma
🇮🇹Verona, Italy
Nippon Medical School - Nippon Medical School Hospital
🇯🇵Bunkyo-ku, Japan
Chiba-Nishi General Hospital
🇯🇵Matsudo-shi, Japan
Kitasato University Hospital (KUH)
🇯🇵Sagamihara-shi, Japan
Sapporo City Hospital
🇯🇵Sapporo-shi, Japan
Hokkaido University Hospital - Rheumatology
🇯🇵Sapporo-shi, Japan
Sasebo Chuo Hospital
🇯🇵Sasebo-shi, Japan
Tohoku University Hospital
🇯🇵Sendai-shi, Japan
Yamaguchi University Hospital
🇯🇵Ube-shi, Japan
Wakayama Medical University Hospital - Dermatology
🇯🇵Wakayama-shi, Japan
Chungnam National University Hospital (CNUH)
🇰🇷Daejeon, Korea, Republic of
Gachon University Gil Medical Center
🇰🇷Incheon, Korea, Republic of
Kyung Hee University Medical Center
🇰🇷Seoul, Korea, Republic of
Seoul National University Hospital
🇰🇷Seoul, Korea, Republic of
Hanyang University Seoul Hospital
🇰🇷Seoul, Korea, Republic of
Ajou University Hospital
🇰🇷Suwon, Korea, Republic of
Hospital of Lithuanian University of Health Sciences Kauno klinikos
🇱🇹Kaunas, Lithuania
Vilnius University Hospital Santaros Klinikos
🇱🇹Vilnius, Lithuania
CITER - Centro de Investigacion y Tratamiento de las Enfermedades Reumaticas S.A. de C.V.
🇲🇽Mexico City, Mexico
Centro Peninsular De Investigacion Clinica
🇲🇽Mérida, Mexico
Amsterdam University Medical Center (Amsterdam UMC), Academic Medical Center (AMC)
🇳🇱Amsterdam, Netherlands
Universitair Medisch Centrum Utrecht (UMC Utrecht)
🇳🇱Utrecht, Netherlands
Hogar Clinica San Juan de Dios
🇵🇪Arequipa, Peru
Investigaciones Clinicas S.A.C.
🇵🇪Lima, Peru
Instituto Peruano Del Hueso Y La Articulacion Sac-Privado-Lima, Centro De Investigacion Iphar
🇵🇪Lima, Peru
Hospital Nacional Cayetano Heredia
🇵🇪Lima, Peru
Szpital Uniwersytecki nr 2 im. Dr Jana Biziela w Bydgoszczy
🇵🇱Bydgoszcz, Poland
Centrum Wsparcia Badan Klinicznych Pomorski Uniwersytet Medyczny w Szczecinie
🇵🇱Szczecin, Poland
USK-WAM Centralny Szpital Weteranow - Szpital Kniniczny ul. Zeromskiego 113
🇵🇱Łódź, Poland
Centro Hospitalar Lisboa Norte, E.P.E- Hospital Santa Maria
🇵🇹Lisboa, Portugal
Centro Hospitalar Universitario de Santo Antonio
🇵🇹Porto, Portugal
Clinical Center of Serbia
🇷🇸Belgrade, Serbia
Hospital Clinic de Barcelona - Sede Villarroel - Rheumatology
🇪🇸Barcelona, Spain
Hospital de la Santa Creu i Sant Pau
🇪🇸Barcelona, Spain
Hospital Universitario Ramon y Cajal
🇪🇸Madrid, Spain
Hospital Universitario La Paz
🇪🇸Madrid, Spain
Hospital Universitario 12 de Octubre
🇪🇸Madrid, Spain
Hospital De Valme
🇪🇸Sevilla, Spain
Hospital Universitario y Politecnico La Fe
🇪🇸Valencia, Spain
Hospital Do Meixoeiro
🇪🇸Vigo, Spain
Karolinska Universitestssjukhus Solna
🇸🇪Stockholm, Sweden
Neurocenter of Southern Switzerland
🇨🇭Lugano, Switzerland
Chung Shan Medical University Hospital
🇨🇳Taichung city, Taiwan
Taichung Veterans General Hospital
🇨🇳Taichung City, Taiwan
China Medical University and Hospital
🇨🇳Taichung, Taiwan
Chulalongkorn University - Faculty of Medicine - King Chulalongkorn Memorial Hospital (KCMH)
🇹🇭Bangkok, Thailand
Phramongkutklao Hospital
🇹🇭Bangkok, Thailand
Ramathibodi hospital
🇹🇭Bangkok, Thailand
Siriraj Hospital, Mahidol University of Internal medicine
🇹🇭Bangkok, Thailand
Khon Kaen University
🇹🇭Khon Kaen, Thailand
Thammasat University Hospital
🇹🇭Pathum Thani, Thailand
Ankara University Medical Faculty
🇹🇷Ankara, Turkey
Ankara City Hospital
🇹🇷Ankara, Turkey
Necmettin Erbakan University Meram Medical Faculty
🇹🇷Konya, Turkey
Aintree University Hospital - Liverpool University Hospitals NHS Foundation Trust
🇬🇧Liverpool, United Kingdom
The Royal Free Hospital - Royal Free London NHS Foundation Trust
🇬🇧London, United Kingdom
Kings College Hospital NHS Foundation Trust
🇬🇧London, United Kingdom
The National Hospital for Neurology and Neurosurgery
🇬🇧London, United Kingdom
James Cook University Hospital - South Tees Hospitals NHS Foundation Trust
🇬🇧Middlesbrough, United Kingdom
Salford Royal Hospital, Northern Care Alliance NHS Foundation Trust
🇬🇧Salford, United Kingdom
Universite Libre de Bruxelles (ULB) - Hopital Erasme
🇧🇪Anderlecht, Belgium
University of Southern California Norris Comprehensive Cancer Center
🇺🇸Los Angeles, California, United States
University Of California - Los Angeles
🇺🇸Los Angeles, California, United States
Stanford Neuroscience Health Center
🇺🇸Palo Alto, California, United States
University of Colorado Denver, Anschutz Medical Campus
🇺🇸Aurora, Colorado, United States
University Of Miami
🇺🇸Miami, Florida, United States
Rush University Medical Center
🇺🇸Chicago, Illinois, United States
The University of Chicago Medical Center (UCMC) - Duchossois Center for Advanced Medicine (DCAM)
🇺🇸Chicago, Illinois, United States
University Of Louisville Healthcare Outpatient Center
🇺🇸Louisville, Kentucky, United States
Ochsner Medical Center (OMC)
🇺🇸New Orleans, Louisiana, United States
University of Minnesota
🇺🇸Minneapolis, Minnesota, United States
Cleveland Clinic
🇺🇸Cleveland, Ohio, United States
Altoona Center for Clinical Research
🇺🇸Duncansville, Pennsylvania, United States
Palmetto Primary and Specialty Care Physicians
🇺🇸Summerville, South Carolina, United States
Texas Neurology, P.A.
🇺🇸Dallas, Texas, United States
University of Texas Southwestern Medical Center
🇺🇸Dallas, Texas, United States
Texas Arthritis Center
🇺🇸El Paso, Texas, United States
The University of Texas Health Science Center at San Antonio
🇺🇸San Antonio, Texas, United States
West Virginia University - Physician Office Center Department of Neurology
🇺🇸Morgantown, West Virginia, United States
West Virginia University School of Medicine (WVUSoM) - Movement Disorder Clinic
🇺🇸Morgantown, West Virginia, United States
Sanatorio Parque S.A y Consultorios Externos Asociados
🇦🇷Rosario, Argentina
Kepler University Hospital
🇦🇹Linz, Austria
Klinikum Wels-Grieskirchen
🇦🇹Wels, Austria
Hospital Hietzing in Vienna
🇦🇹Wien, Austria
Universitair Ziekenhuis Gent
🇧🇪Gent, Belgium
Associacao de Assitencia a Crianca Deficiente(AACD)
🇧🇷Sao Paulo, Brazil
Multiprofile Hospital for Active Treatment - Plovdiv AD
🇧🇬Plovdiv, Bulgaria
DCC Sveti Georgi
🇧🇬Plovdiv, Bulgaria
Clinic of Rheumatology Multiprofile Hospital for Active Treatment Sveti Ivan Rilski
🇧🇬Sofia, Bulgaria
University of Alberta - Mazankowski Alberta Heart Institute (MAHI)
🇨🇦Edmonton, Canada
Applied Medical Informatics Research Inc. (A.M.I.R.)
🇨🇦Montreal, Canada
China-Japan Friendship Hospital
🇨🇳Beijing, China
Mayo Clinic
🇺🇸Jacksonville, Florida, United States
Washington University School of Medicine
🇺🇸Saint Louis, Missouri, United States
Mercy Hospital - Mercy Clinic Neurology Oklahoma City - Neurology
🇺🇸Oklahoma City, Oklahoma, United States
Centre Hospitalier Universitaire de Charleroi
🇧🇪Charleroi, Belgium
Peking University First Hospital
🇨🇳Beijing, China
Peking University Third Hospital
🇨🇳Beijing, China
Peking Union Medical College Hospital
🇨🇳Beijing, China
The First Hospital of Jilin University
🇨🇳Changchun, China
Xiangya Hospital Central South University
🇨🇳Changsha, China
The Second Xiangya Hospital of Central South University
🇨🇳Changsha, China
Sichuan Provincial Peoples Hospital
🇨🇳Chengdu, China
Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University
🇨🇳Guangzhou, China
Nanfang Hospital, Southern Medical University
🇨🇳Guangzhou, China
The First Affiliated Hospital - School of Medicine - ZheJiang University
🇨🇳Hangzhou, China
Anhui Provincial Hospital
🇨🇳Hefei, China
The Second Affiliated Hospital Of Nanchang University
🇨🇳Nanchang, China
Nanjing Drum Tower Hospital
🇨🇳Nanjing, China
Huashan Hospital Affiliated to Fudan University
🇨🇳Shanghai, China