Effect of Carbonated Soft Drinks on Appetite-Regulation

Not Applicable

Completed

• Conditions: Obesity; Diet
• Interventions: Other: Sugar-sweetened soft drink; Other: Aspartame-sweetened soft drink; Other: Semi-skimmed milk; Other: Water

• Registration Number: NCT00776971
• Lead Sponsor: Aarhus University Hospital

Brief Summary

Compared to solid foods, the nutritional energy of drinks may bypass the appetite regulation leading to obesity development. Although drinks sweetened with aspartame are available the anticipated positive effect of these drinks on obesity development has not been convincing. However, the mechanisms linking drinks intake to obesity are yet to be clarified.

The investigators aim is to investigate the short-term effects of soft drinks (sugar-sweetened and artificially sweetened (aspartame)), milk and water on the concentration of circulating appetite-regulating hormones, the subjective sensations of hunger and satiety (measured by visual analogue scales) and energy intake. The study is a crossover, intervention trial with 24 overweight, healthy volunteers. The subjects will be tested on four separate days for four hours. Each test day a preload drink (sugar-sweetened soft drink, aspartame-sweetened soft drink, semi-skimmed milk or water) is served.

The investigators expect to clarify the mechanisms linking drinking habits to obesity development and provide scientifically based nutritional guidelines.

Detailed Description

Not available

Study Timeline

• Study Start: 2007-11
• Status Verified: 2008-08
• Primary Completion: 2008-09
• Study Completion: 2008-09
• Study First Submitted: 2008-10-21
• Study First Submitted QC: 2008-10-21
• Last Update Submitted: 2008-10-21
• Study First Posted: 2008-10-22
• Last Update Posted: 2008-10-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

• Age between 20-50 years;
• BMI between 28-36 kg/m2;
• Weight stabile 3 months prior to the study inclusion;
• Less than 10 hours of weekly exercise.

Exclusion Criteria

• Diabetes
• Allergic to phenylalanine or milk
• Smoking
• Pregnancy or breast-feeding

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Sugar-sweetened soft drink	Sugar-sweetened soft drink	54g sugar/L, 180kJ/100mL
Aspartame-sweetened soft drink	Aspartame-sweetened soft drink	1.5kJ/100mL
Semi-skimmed milk	Semi-skimmed milk	202kJ/100mL
Water	Water	0kJ/100mL

Primary Outcome Measures

Name	Time	Method
Visual Analogue Scale	Four hours

Secondary Outcome Measures

Name	Time	Method
Appetite-regulating hormones, Glucose, Insulin; Energy intake	Four hours

Trial Locations

Locations (1)

Department of Internal Medicine/Endocrinology C, Aarhus University Hospital; 🇩🇰 Aarhus, Denmark